Acta Scientific Otolaryngology (ASOL)

Research Article Volume 2 Issue 1

The Role of Local Treatment in Recurrent and Persistent Cases of Rhinisinusitis without Polyposis

Hany Amin*, Ahmed Abdel Ghani, Moustafa Gomaa Sobhy, Samah Mahmoud Eldousky and Tahani Mohamed Rabea

Professor of Otolaryngology and Head and Neck Surgery, Benha University, Saudi Arabia

*Corresponding Author: Hany Amin, Professor of Otolaryngology and Head and Neck Surgery, Benha University, Saudi Arabia. E-mail: hanye55amin@gmail.com

Received: January 06, 2020; Published: January 20, 2020

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Abstract

Introduction: The chronic non polypoidal rhinosinusitis is a frequent disease causing patients disability and repeated symptoms. The systemic treatment is not effective in many cases. Surgery is expansive and not suitable every patient. Mucociliary mechanism is affected by various conditions mainly temperature, ph, viscosity, osmolality, electrolytes, neural balance between sympathetic and parasympathetic systems, hormonal and local infection (biofilm).

Aim of the Study: So we are trying to focus on local treatment as a modality of treatment which can be used with the other types of treatment.

Methods: This is a prospective single-blinded (clinician only) randomized controlled trial recruited patients with active CRS without polyposis. In this study we will compare several local treatment to evaluate its efficacy and potency through evaluating the local treatment changes on the mucociliary mechanism of the rhinosinusitis patients and in treating chronic rhinosinusitis.

  As local antifungal, local antibiotic, saline nasal wash, local corticosteroids and honey compound. Evaluation of the mucociliary mechanism was done for all patients by estimating the mucous motility with saccharine test and one of its main content which is of utmost importance for nasal ciliary function which is the ph of the mucus.

  However the ciliary action was estimated through scanning electron microscopy, The same procedures were repeated after 6 months of treatment.

Results: From these studies we had reached that the repetition of the results of different experiments gave a conclusion about the efficacy of the honey as a local treatment of our study cases.

Conclusion: Chronic rhinosinsitis does not affect the mucociliary system not only by the microbal affection and toxicity but also in changing the main factors which are responsible for its function.

  Treatment should targeting all the altered factors that affect the mucociliary physiology we should pay more attention to local treatment as a modality of treatment that can deal with the multifactorial process of regaining a healthy mucociliary system.

Keywords: Mucociliary; Endoscopy; Chronic Disease

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References

  1. Adams PF., et al. “Center for Health Statistics Current estimates from the National Health Interview Survey, 1996”. Vital and Health Statistics 200 (1999): 1-203.
  2. Collins JG. “Prevalence of selected chronic conditions: United States, 1990-1992”. Vital and Health Statistics 10.194 (1997): 1-89.
  3. Hastan D., et al. “Chronic rhinosinusitis in Europe - an underestimated disease. A GA (2)LEN study”. Allergy 66.9 (2011): 1216-1223.
  4. Hany M Amin., et al. “E.N.T. Diseases Profile in Kalyobia”.
  5. AHMAD R SEDAGHAT. Chronic Rhinosinusitis. Harvard Medical School, Boston, Massachusetts. American Family Physician 96.8 (1997): 500-506.
  6. Anatomy, Head and Neck, Nasal Cavity Authors Sobiesk JL, Munakomi S2. SourceStatPearls [Internet]. Treasure Island (FL): StatPearls Publishing (2019).
  7. Erica Ortiz., et al. “Rhinosinusitis in hematopoietic stem cell-transplanted patients: influence of nasosinus mucosal abnormalities?” Stem Cell Research and Therapy 5 (2014).
  8. Wilson WR and Allansmith MR. “Rapid, a traumatic method for obtaining nasal mucus samples”. Annals of Otology, Rhinology, and Laryngology 85 (1976): 391-393.
  9. Rahmoune H and Shephard KL. “State of airway surface liquid on guinea pig trachea”. Journal of Applied Physiology 78 (1995): 2020-2024.
  10. Gizurarson S. “Animal models for intranasal drug delivery studies. A review article”. Acta Pharmaceutica Nordica 2 (1990): 105-122.
  11. Alberty J., et al. “The effect of endogenous nitric oxide on mechanical cilio stimulation of human nasal mucosa”. Clinical and Experimental Allergy 36 (2006): 1254-1259.
  12. Laoukili J., et al. “IL-13alters mucociliary differentiation and Ciliary beating of human respiratory epithelial cells”. Journal of Clinical Investigation 108 (2001): 1817-1824.
  13. Muns G., et al. “Impaired nasal mucociliary clearance in long distance runners”. International Journal of Sports Medicine 16 (1995): 209-213.
  14. Messerklinger W. “Über die Sekretströmung auf der Schleimhaut deroberen Luftwege”. Zeitschrift für Laryngologie, Rhinologie, Otologie 30 (1951): 302-308.
  15. Swart SJ., et al. “Immunoglobulin concentration sinnasal secretions differ between patients with an IgE-mediated rhinopathy and a non-IgE- mediated rhinopathy”. Journal of Allergy Clinical Immunology 88 (1991): 612-619.
  16. Washington N and Steeler Jackson. “Determination of baseline human nasal PH and effect of intranasal administrative buffer”. Journal of Pharmaceutical 198 (2000): 139-146.
  17. Proctor Donald F. The Nose: Upper Airway Physiology and the Atmospheric Environment. Elsevier Biomedical Press (1982).
  18. Gelardi M., et al. “Assessment of biofilm by nasal cytology in different forms of rhinitis and its functional correlations”. European Annals of Allergy and Clinical Immunology 45.1 (2013): 25-29.
  19. Toskala., et al. “Scanning electron microscopy findings of human respiratory cilia in chronic sinusitis and in recurrent respiratory infections”. The Journal of Laryngology and Otology 109.6 (1995): 509-514.
  20. Gizurarson S. “The effect of cilia and the mucociliary clearance on successful drug delivery”. Biological and Pharmaceutical Bulletin 38.4 (2015): 497-506.
  21. Fernanda Rodrigues., et al. “Particularities and Clinical Applicability of Saccharin Transit Time Test”. International Archives of Otorhinolaryngology 23.2 (2019): 229-240.
  22. Hany Amin Riad., et al. “Follow up of changes in maxillary sinus mucosa after functional endoscopic sinus surger: endoscopic, light and electron microscopic study” (2018).
  23. Pandya VK and Tiwari RS. “Nasal mucociliary clearance in health and disease”. Indian Journal of Otolaryngology and Head and Neck Surgery 58.4 (2006): 332-334.
  24. Singh M., et al. “Role of measurement of nasal mucociliary clearance by saccharine test as a yard stick of success of functional endoscopic sinus surgery”. Indian Journal of Otolaryngology and Head and Neck Surgery 62.3 (2010): 289-295.
  25. Plaza Valía P., et al. “Saccharin test for the study of mucociliary clearance: reference values for a Spanish population”. Archivos de Bronconeumología 44 (2008): 540-545.
  26. Murat Yasar., et al. “Evaluation of the effects on nasal mucociliary clearance of various nasal solutions applied topically in patients with sinusitis”. Medicine Science International Medical Journal 24 (2017).
  27. Delehaye E., et al. “Correlation between nasal mucociliary clearance time and gastroesophageal reflux disease: our experience on 50 patients”. Auris Nasus Larynx 36 (2009): 157-161.
  28. Habesoglu M., et al. “Does passive smoking have an effect on nasal mucociliary clearance?” Otolaryngology–Head and Neck Surgery 147 (2012): 152-156.
  29. Inglis SK., et al. “Effect of anion secretion inhibitors on mucin content of airway submucosal gland ducts”. American Journal of Physics 247 (2001): 762-766.
  30. Selimoglu MA., et al. “Nasal mucociliary clearance and nasal and oral pH in patients with insulin - dependent diabetes”. Ear, Nose and Throat Journal 78 (2008): 585-599.
  31. Jasmim Leal., et al. “Physicochemical properties of mucus and their impact on transmucosal drug delivery”. International Journal of Pharmacy 532.1 (2017): 555-572.
  32. RJA England., et al. “Nasal pH measurement: a reliable and repeatable parameter”. Clinical Otolaryngology and amp Allied Sciences (2001).
  33. Kim BG., et al. “Nasal pH in patients with chronic rhinosinusitis before and after endoscopic sinus surgery”. American Journal of Otolaryngology 34.5 (2013): 505-507.
  34. Mouwafak M., et al. “Changes in nasal epithelium in patients with severe chronic sinusitis: A clinicopathologic and electron microscopic study†First” (1998).
  35. Lee VS., et al. “Int Forum Manuka honey sinus irrigation for the treatment of chronic rhinosinusitis: a randomized controlled trial”. Allergy and Rhinology 7 (2017): 365-372.
  36. Hashemian F., et al. “The effect of thyme honey nasal spray on chronic rhinosinusitis: a double-blind randomized controlled clinical trial”. European Archives of Oto-Rhino-Laryngology 272.6 (2015): 1429-1435.
  37. Paramasivan S., et al. “Methylglyoxal-augmented manuka honey as a topical anti- Staphylococcus aureus biofilm agent: safety and efficacy in an in vivo model”. International Forum of Allergy and Rhinology 4.3 (2014): 187-195.
  38. Manisha Deb Mandal and Shyamapada Mandal. “Honey: its medicinal property and antibacterial activity”. Asian Pacific Journal of Tropical Biomedicine 1 (2011): 154-160.
  39. Chang X., et al. “Antioxidative, anti browning and antibacterial activities of sixteen floral honeys”. Food and Function 2 (2011): 541-546.
  40. Chong LY., et al. “Saline irrigation for chronic rhinosinusitis”. Cochrane Database System Review 26 (2016): CD011995.
  41. Head K., et al. “Systemic and topical antibiotics for chronic rhinosinusitis”. Cochrane Database System Review (2016).
  42. Farshad Hashemian., et al. “Linical effects of topical antifungal therapy in chronic rhinosinusitis: a randomized, double-blind, placebo-controlled trial of intranasal fluconazole”.
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Citation

Citation: Hany Amin., et al. “The Role of Local Treatment in Recurrent and Persistent Cases of Rhinisinusitis without Polyposis". Acta Scientific Otolaryngology 2.2 (2020): 01-12.




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