Acta Scientific Nutritional Health (ASNH)(ISSN: 2582-1423)

Research Article Volume 4 Issue 1

Association of Glyoxalase 1 Gene Variations and Altitude Residency in Taif, Saudi Arabia

Alaa Shafie1,2*

1Collage of Applied Medical Sciences, Taif University, Taif City, Saudi Arabia
2High Altitude Research Center, Taif University, Taif City, Saudi Arabia

*Corresponding Author: Alaa Shafie, Collage of Applied Medical Sciences and High Altitude Research Center, Taif University, Taif City, Saudi Arabia.

Received: December 18, 2019; Published: December 27, 2019

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Abstract

  Altitude residency is associated with hypoxic stress. Hypoxia is one of the major stresses affecting human body. Human living in altitude have adopted genetically and physiologically to this stress to permit their health, survival and reproduction in such environment. Many gene variations are associated with living in altitude. This study aims to investigate the association between Glo1 gene variations and living in altitude. In total 80 blood samples were collected from altitude city (Taif) and 80 blood samples from sea level city (Jeddah). Glo1 copy number and Glo1 SNP were investigated after the DNA extraction. The genotyping of Glo1 polymorphism was analysed by PCR and RFLP and then digested using SfaNI digestive enzyme. The copy number of Glo1 was determined by TaqMan® Copy Number Assays. The genotype differences between both populations was not significant and no association has been identified between Glo1 gene variations and living in altitude. Further studies are needed to investigate this association using samples from people living consistently in higher altitude than Taif city and other variation including epigenetics variations.

Keywords: Hypoxia; Altitude; Glyoxalase 1; Genetics; Taif

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Citation

Citation: Alaa Shafie. “Association of Glyoxalase 1 Gene Variations and Altitude Residency in Taif, Saudi Arabia". Acta Scientific Nutritional Health 4.1 (2020): 145-148.



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