Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Review Article Volume 3 Issue 1

Neurological Diseases Associated with Brain Iron Accumulation

Rajib Dutta1* and Swatilekha Roy Sarkar2#

1MD, Neurology, India

2MDS, Consultant Orthodontist, India

*Corresponding Author: Rajib Dutta, MD, Neurology, India. E-mail: rajibdutta808@gmail.com

Received: December 27, 2019; Published: December 31, 2019

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Abstract

  Brain iron plays a very important role in maintaining normal physiological functioning and homeostasis. However, excess iron or dysregulated iron metabolism is a potent source of free radical formation and oxidative damage to neuronal and other brain cells. Abnormal high brain iron levels are associated with many neurological diseases like Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Neurodegeneration with brain iron accumulation, Multiple sclerosis, Aceruloplasminaemia (CPM). etc. Here in this review we will focus on brain iron transport, dysregulated metabolism and the disease it causes.

Keywords: Brain Iron; Neurodegeneration; Neurodegenerative Mechanisms; Neuroinflammation; Mitochondria; Neuron; Cells; Iron Metabolism; Blood Brain Barrier; Blood CSF Barrier; Influx; Efflux

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Citation

Citation: Rajib Dutta and Swatilekha Roy Sarkar. “Neurological Diseases Associated with Brain Iron Accumulation".Acta Scientific Neurology 3.1 (2020): 53-61.



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