An Innovative Way to Create and Treat the Purulent Liver Abscess in a Surgical Experiment
The Rasumovsky Saratov State Medical University, Saratov, Russian Federation
*Corresponding Author: Alipov VV, The Rasumovsky Saratov State Medical University, Saratov, Russian Federation.
April 12, 2021; Published: June 23, 2021
Relevance: The development of new methods for creating liver abscesses will allow us to clarify diagnostic standards and justify new minimally invasive methods of surgical intervention and postoperative therapy. The aim is to experimentally substantiate an innovative method for creating a HAP and the effectiveness of the combined use of low-intensity laser radiation (LLI) and metal nanocomplex (NC) in the surgical treatment of liver abscesses. Material and methods. The creation of a liver abscess was carried out in an experiment on 80 laboratory rabbits. In a certain proportion of the liver under the control of ultrasound for 5 days was carried out with an infected modified catheter with a silicone rubber balloon at the distal end, where a polystam of staphylococcus and Escherichia coli was used as the causative agent of the pathological process, while a delimited gap cavity was formed.
Treatment: PLA was performed for 14 days, and the animals were divided into 4 groups of 20 in each. The animals of the first group were sanitized with furacilin and the cavity the use of antibiotics. Animals of the second group underwent cavity and NILI sanitation. Animals of the third group underwent cavity sanitation using a 0.24% solution of intralipid containing NK. Animals of the fourth group underwent sanitation of the abscess cavity in combination with the introduction of NK and the use of NILI. Clinical, planimetric, microbiological, morphological, and instrumental methods were used to confirm the simulated abscess.
Results and Discussion: Performing a transcutaneous puncture of the liver with laser support provides reliable cholestasis and hemostasis using an infected two-channel catheter with a balloon guarantees the formation of a GAP with the specified characteristics in a short time. Combined use of NC and NILI provides purification from the pathogen of the PLA cavity by the 7th day of treatment and complete obliteration of the abscess cavity by the 20th day of treatment.
Keywords: Purulent Liver Abscess (PLA); Metal Nanocomplex (NC); Low-intensity Laser Irradiation (LLI)
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