Activity of Apoptosis Markers in HPV-Associated Cervical Pathologies
Vinogradova OP1*, Orlova EA1, Artemova OI2 and Epifanova OV1
1Branch of FSBEI FPE “Russian Medical Academy of Postgraduate Education” of the Ministry of Healthcare of the Russian Federation, Russia
2Scientific Research Institute of Fundamental and Applied Research "("NIIFiPI") FSBEI HE Penza State University”, Russia
*Corresponding Author: Vinogradova OP, Doctor of Medical Sciences, Professor, Branch of FSBEI FPE “Russian Medical Academy of Postgraduate Education” of the Ministry of Healthcare of the Russian Federation, Russia.
Received: March 02, 2021; Published: May 27, 2021
Difficulties in managing patients with cervical intraepithelial neoplasia (CIN) encountered in the work of practicing physicians are determined, firstly, by the lack of uniform treatment and diagnostic measures for cervical precancer and its prevention, and secondly, with insufficient understanding of the processes of human papillomavirus (HPV) -induced squamous intraepithelial lesions, mechanisms of action of anti-HPV drugs and, as a consequence, irrational ways of affecting the cervical tissue. In this regard, it seems relevant to develop and clinically test the use of etiopathogenetic effects on the initiating factors and cofactors of oncogenesis in order to create an optimal-radical effect that allows achieving complete regression of the pathological focus. This will reduce the frequency of neoplastic transformation of the cervix in women of the reproductive period, as well as improve the results of treatment and improve the quality of life of patients.
Keywords: Ectocervical Dysplasia; Caspase-1; Caspase-3; Caspase-9; Apoptosis-resistant Phenotype
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