Nikha Garg1, Anu Chandra2*, MR Srivastava3 and KS Dhillon1
1Department of Dermatology, Venereology and Leprosy, Era’s Lucknow Medical College and Hospital, Era University, Dumka Medical College, Dumka, India
2Department of Biochemistry, Era’s Lucknow Medical College and Hospital, Era University, Dumka Medical College, Dumka, India
3Department of Community Medicine, Era’s Lucknow Medical College and Hospital, Era University, Dumka Medical College, Dumka, India
*Corresponding Author: Anu Chandra, Professor, Department of Biochemistry, Era’s Lucknow Medical College and Hospital, Era University, Dumka Medical College, Dumka, India.
Received: July 23, 2020; Published: October 22, 2020
Introduction: Polymorphic light eruption is the commonest photosensitive disorder, characterized by an intermittent eruption of non-scarring erythematous papules, vesicles or plaques that develop within hours of ultraviolet radiation exposure of patient skin. Together with the lesions, a terrible itch starts and increases with the spreading of the disease, sometimes aggravated by a sort of burning sensation. The exact pathogenesis of PLE is currently unknown but findings suggest that an abnormal immune response is responsible for the tissue damage in PLE. For prophylaxis besides conventional sunscreens phototherapy is effective in many cases, when administered over several weeks.
Material and Methods: The present study was carried out in the Department of Dermatology, Sexually Transmitted Diseases and Leprosy and the Department of Biochemistry of Era’s Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh. In this study 60 clinically diagnosed polymorphic light eruption patients and 30 age, sex and BMI matched controls were included. The design of the study was interventional study comprising two Interventional groups and a control group. The patients were divided into two groups randomly and treatment was constituted accordingly.
Observation and Results: The study evaluates clinic-investigative profile and serum vitamin D levels in patients with polymorphic Light Eruption. A total of 60 symptomatic patients who served as our experimental group and 30 normal healthy individuals, post hoc matched for age, sex and demographics were recruited and evaluated.
Estimation of serum 25-hydroxy-vitamin D3 levels in PLE patients and control group showed that the mean vitamin D3 level in PLE patients (15.98 ± 7.11 ng/mL) was significantly lower (p < 0.001) than the level seen in controls (30.97 ± 6.58 ng/mL). Majority of the PLE patients had insufficient (50%) or deficient (41.7%) Vitamin D3 levels while most of the individuals in the control group had optimal vitamin D3 status (70%) representing a significant gap (p < 0.001) amongst the two groups.
Conclusions: The results of this study clearly indicate that treatment with oral vitamin D3 supplement significantly diminished the appearance and severity of PLE symptoms in the study participants. A statistically significant reduction (p < 0.001) of PLE test scores by 33.3% was observed in patients receiving oral vitamin D3 supplementation for 3 weeks along with photoprotection in the form of topical sunscreen application (5.31 ± 1.73 vs. 3.54 ± 1.78).
Keywords: Polymorphic Light Eruption; Photosensitive; Ultraviolet Radiation Exposure; 25-hydroxy-vitamin D3; Photoprotection
Citation: Anu Chandra., et al. “Correlation between Serum Vit D3 Levels and Clinicoepidemiological Profile of Polymorphic Light Eruption Patients: An Interventional Study". Acta Scientific Medical Sciences 4.11 (2020): 70-78.
Copyright: © 2020 Anu Chandra., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.