Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
*Corresponding Author: Anuradha Ratna, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Received: July 30, 2018; Published: August 10, 2018
Citation: Anuradha Ratna. “Inflammasome and its Component NLRP3 Plays a Major Role in Tumorigenesis”. Acta Scientific Medical Sciences 2.6 (2018).
Chronic inflammation plays a crucial role at different stages of tumor development, including initiation, invasion and metastasis [1-4]. Many cancers are associated with chronic inflammation, for instance, hepatocarcinoma from Hepatitis B or C virus infection, gastric cancer due to Helicobacter pylori and colorectal cancer from ulcerative colitis [5,6]. Altered cell signaling pathways involving kinases and their downstream transcription factors have been established as the major contributors associated with inflammationinduced carcinogenesis . Inflammation, particularly involving inflammasomes, modulates carcinogenesis through secretion of various inflammatory cytokines. Inflammasome is an important multimolecular complex formed by NOD-like receptor (NLR) family members that regulates inflammatory immune responses by activating proteolytic enzyme caspase-1 . Activation of inflammasome via canonical pathway promotes caspase-1 dependent maturation of proinflammatory cytokines IL-1β and IL-18 as well as induces pyroptotic cell death in response to pathogen-associated molecular patterns or endogenous danger signals . Proinflammatory cytokines attracts a myriad of immune cells such as neutrophils, macrophages, monocytes and leukocytes to organize a local immune network within tumor microenvironment. In inflammatory cells, caspase-1 activation can initiate pathways leading to sterile inflammation, production of trophic factors required for cancer cells and their stroma .
Copyright: © 2018 Anuradha Ratna. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.