Acta Scientific Microbiology (ISSN: 2581-3226)

Research Article Volume 3 Issue 1

The Influence of Nitrile Acrylate Acute Intoxication on the Stem Cell Migration from Bone Marrow to Spleen and the Parameters of Innate and Adaptive Immunity

Pavel Franzevich Zabrodskii*

Saratov Medical University "REAVIZ", Saratov, Russia

*Corresponding Author: Pavel Franzevich Zabrodskii, Saratov Medical University "REAVIZ", Saratov, Russia.

Received: November 11, 2019; Published: December 11, 2019

×

Abstract

   Experiments on random-bred albino mice and rats showed that nitrile acrylate acute intoxication (0.25 and 0.75 LD50) dose-dependent reduces the integral state of the organism's anti-infection nonspecific resistance (innate immunity) due to suppression of bactericidal activity of blood serum, serum concentrations of lysozyme, platelet cationic protein, functional activity of neutrophils, increased the mortality rate of mice in comparison with the control and CFUs of opportunistic flora in peripheral blood and spleen. The action of nitrile acrylate in direct dose dependence reduces the stem cell migration from bone marrow to spleen and the basic parameters of innate and adaptive immunity.

Keywords: Nitrile Acrylate; Immunotoxicity; Stem Cell Migration; Innate Immunity; Adaptive Immunity; E. Coli

×

References

  1. PF Zabrodskii. “Immunotropic properties of poisons and drugs”. Saratov State Medical University (1998): 213.
  2. Zabrodskii PF and Mandych VG. “Immunotoxicology of xenobiotics”. Saratov Military Institute of Biological and Chemical Safety (2007): 420.
  3. PF Zabrodskii. “Influence of xenobiotics on immune homeostasis”. In: General toxicology. Ed. BA. Kurlyandsky, VA. Filov. Moscow. Medicine (2002): 352-384.
  4. Chang CM., et al. “Acrylonitrile-induced sister-chromatid exchanges and DNA single-strand breaks in adult human bronchial epithelial cells”. Mutation Research 4 (1990): 355-360.
  5. Hamada FM., et al. “Possible functional immunotoxicity of acrylonitrile (VCN)”. Pharmacological Research2 (1998):123-129.
  6. Tucek M., et al. “Effect of acrylate chemistry on human health”. International Archives of Occupational and Environmental Health 75 (2002): 67-72.
  7. Zabrodskii PF., et al. “Mechanisms of immunotoxic effects of acrylonitrile”. Bulletin of Experimental Biology and Medicine5 (2000): 463-465.
  8. Zabrodskii PF., et al. “Changes in immunity parameters and blood cytokine concentrations after chronic nitrile acrylate intoxication”. Bulletin of Experimental Biology and Medicine2 (2014): 238-241.
  9. Zabrodskii PF., et al. “Effect of the cholinesterase reactivator dipyroxime in various models of delayed hypersensitivity during acute intoxication by acrylonitrile”. Eksperimental'naia I Klinicheskaia Farmakologiia 63 (2000): 47-49.
  10. Zabrodskii PF. “Effect of armin on nonspecific resistance factors of the body and on the primary humoral immune response”. Farmakologiia I Toksikologiia1 (1987): 57-60.
  11. PF Zabrodskii. “Immunotoxicology of organophosphorus compounds”. Saratov (2016): 289.
  12. Song DJ., et al. “Effect of lentiviral vector encoding on triggering receptor expressed on myeloid cells 1 on expression of inflammatory cytokine in septic mice infected by Bacteroides fragilis”. Zhonghua Shao Shang Za Zhi1 (2009): 36-41.
  13. Till JE and McCulloch EA. “A direct measurement of the radiation sensitivity of normal mouse bone marrow cells”. Radiation Research2 (1961): 213-222.
  14. Male D., et al. “Immunology”. 7th Ed’. Elsevier (2006): 563.
  15. Kimber I. “Chemical – Induced Hypersensitivity”. In.: Exper. Immun. Boca Raton, New York, London Tokyo (1996): 391-417.
×

Citation

Citation: Pavel Franzevich Zabrodskii. "The Influence of Nitrile Acrylate Acute Intoxication on the Stem Cell Migration from Bone Marrow to Spleen and the Parameters of Innate and Adaptive Immunity".Acta Scientific Microbiology 3.1 (2020): 80-83.



Member In






News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for March Issue
    The last date for submission of articles for regular Issues is March 15, 2020.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US