Acta Scientific Microbiology (ISSN: 2581-3226)

Research Article Volume 3 Issue 1

The Cholinergic Anti-Inflammatory Pathway. Combined Effect of Anticholinesterase Compounds and its Antidote Cholinesterase Reactivator Carboxim

Pavel Franzevich Zabrodskii

Saratov Medical University "REAVIZ", Saratov, Russia

*Corresponding Author: Pavel Franzevich Zabrodskii, Saratov Medical University "REAVIZ", Saratov, Russia.

Received: October 28, 2019; Published: December 11, 2019

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Abstract

   Experiments on random-bred albino mice showed that the acute intoxication of anticholinesterase compounds (DDVP, 0.75 LD50) is implemented the cholinergic anti-inflammatory pathway (reduced mortality of mice from sepsis and the blood concentration of proinflammatory cytokines TNF-α, IL-1β, IL-6). Sepsis caused by the intraperitoneal administration of saline diurnal culture of E. coli O157:H7 (2.5×109 CFUs). The use of the cholinesterase reactivator сarboxim (15 mg/kg) - antidote of organophosphorus compounds - after acute intoxication of DDVP diminished affect the implementation of the cholinergic anti-inflammatory pathway.

Keywords: Anti-Inflammatory Pathway; Sepsis; E. Coli; Anticholinesterase Compounds; Cholinesterase Reactivator Сarboxim

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Citation

Citation: Pavel Franzevich Zabrodskii. "The Cholinergic Anti-Inflammatory Pathway. Combined Effect of Anticholinesterase Compounds and its Antidote Cholinesterase Reactivator Carboxim".Acta Scientific Microbiology 3.1 (2020): 70-73.



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