Pavel Franzevich Zabrodskii
Saratov Medical University "REAVIZ", Saratov, Russia
*Corresponding Author: Pavel Franzevich Zabrodskii, Saratov Medical University "REAVIZ", Saratov, Russia.
Received: October 28, 2019; Published: December 11, 2019
Experiments on random-bred albino mice showed that the acute intoxication of anticholinesterase compounds (DDVP, 0.75 LD50) is implemented the cholinergic anti-inflammatory pathway (reduced mortality of mice from sepsis and the blood concentration of proinflammatory cytokines TNF-α, IL-1β, IL-6). Sepsis caused by the intraperitoneal administration of saline diurnal culture of E. coli O157:H7 (2.5×109 CFUs). The use of the cholinesterase reactivator сarboxim (15 mg/kg) - antidote of organophosphorus compounds - after acute intoxication of DDVP diminished affect the implementation of the cholinergic anti-inflammatory pathway.
Keywords: Anti-Inflammatory Pathway; Sepsis; E. Coli; Anticholinesterase Compounds; Cholinesterase Reactivator Сarboxim
Citation: Pavel Franzevich Zabrodskii. "The Cholinergic Anti-Inflammatory Pathway. Combined Effect of Anticholinesterase Compounds and its Antidote Cholinesterase Reactivator Carboxim".Acta Scientific Microbiology 3.1 (2020): 70-73.
Copyright: © 2020 Pavel Franzevich Zabrodskii. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.