K Abraham Peele, M Indira, S Krupanidhi, Nazneen Bobby, N Sanjana, D John Babu, A Venkata Narayaana and TC Venkateswarulu*
Department of Bio-Technology, Vignan’s Foundation for Science, Technology and Research, Andhra Pradesh, India
*Corresponding Author: TC Venkateswarulu, Department of Bio-Technology, Vignan’s Foundation for Science, Technology and Research, Andhra Pradesh, India.
Received: December 16, 2019; Published: January 11, 2020
Acinetobacter infections are difficult-to-treat because of their resistance patterns. Bacteria have been developing broader range of resistance against many drugs used in treating infections, the discovery of new lead compounds requires a safe strategy to combat as antimicrobials. Therefore, identification of natural compounds is highly essential for developing lead antibiotic like drugs and hence, the study is aimed at identifying the potential compound through computational screening. Computational screening for identification of potential antibiofilm agent was performed using Pub Chem database. The 3D structure model of Acyl-homoserine-lactone synthase (AHL) protein was built using Modeller 9.19 Version. Twenty five compounds were selected for screening of Antibiofilm activity against Acinetobacter baumannii. In computational analysis, virtual screening was performed on only one compound namely: Parecoxib. In-silico screening, identified Parecoxib as a potential inhibitor for AHL synthase of A. baumannii. Our results suggest that Parecoxib can be developed as a lead anti-biofilm drug to treat patients infected with Acinetobacter baumannii.
Keywords: A. baumannii; Acyl-Homoserine Lactone Synthase; Parecoxib; Docking
Citation: TC Venkateswarulu., et al. “In-SilicoM/em> Screening of Antibiofilm Activity Against Acinetobacter Baumannii Species". Acta Scientific Microbiology 3.2 (2020): 01-04.
Copyright: © 2020 TC Venkateswarulu., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.