Acta Scientific Microbiology (ASMI) (ISSN: 2581-3226)

Review Article Volume 3 Issue 2

Analytical Variables in the Clinical Laboratory

Victor Lage de Araujo*

Laboratory Medicine, Brazil, International Fellow, College of American Pathologist, Msc, Evidence-Based Healthcare (UCL)

*Corresponding Author: Victor Lage de Araujo, Laboratory Medicine, Brazil, International Fellow, College of American Pathologist, Msc, Evidence-Based Healthcare (UCL).

Received: December 23, 2019; Published: January 10, 2019

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Abstract

  All patients go to the doctors to assess their health status, and there is seldom a medical appointment in which the doctors do not order a laboratory exam – from the very common urinalysis, stool examination, and Complete Blood Count to some very specific and sometimes intricate exams. Yet most doctors and patients are unaware of some needful procedures that must occur before a result is reported [1, 5, 6]. Not all people are aware of the requisitions of reproducibility, precision and accuracy any lab exam must have if it is going to be useful for their needs: most people still treat laboratory exams as some kind of magic where the report will intrinsically lead to the best judgment by the clinician.

Objective

  If that is to change, both patients and Doctors must know what the best practical procedures are, and how each of the involved people can collaborate. While demonstrating why some errors and inadequacies as to Laboratory exams and their use can sometimes happen, this article focus on the fact that any laboratory must be treated as a highly precise industry [38] – with correspondingly complex and complete procedures – if they intend their reports to be suitable for daily clinical use and comparable from past, present and future results – of any given Laboratory.

Keywords: Analytical; Clinical

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References

  1. Araujo VL. “The Merry-Go-Round of Modern Diagnosis”. Acta Scientific Microbiology 3.1 (2019): 124-129.
  2. ARTEL. Lab Report e-book (2019). 
  3. ARTELa. Facilitating Assay Transfer by Controlling Liquid Handling Variables (2019). 
  4. ARTELb. Supported applications. ELISA. NGS. Callibration. Pipette user training (2019). 
  5. Astion M. “Smoothing workflow and reducing errors in specimen processing: An interview with Albert Dalbello Jr and Linda Nesberg”. Clinical Laboratory News 35.7 (2009): 14-15. 
  6. Astion M. “Reducing Errors in Manual Processes”. When We Can’t Automate, What’s the Best Way to Reduce Errors? (2014). 
  7. Basques JC. ‘Curso de validação de métodos - Tutorial’, in: Congresso Brasileiro de Patologia Clinica Medicina Laboratorial, 52., 2018. Florianópolis, SC: SBPCML (2016): 25. 
  8. BBC. Fall of Berlin Wall: How reshaped the modern world (1989). 
  9. Berger D. “A brief history medical diagnosis and the birth of the clinical laboratory. Parts 1 to 5b- the foundation of molecular science and genetics”. Medical Laboratory Observer 38.9 (2006): 16-18. 
  10. Bottino L. “Ferramentas do controle de qualidade analítico: da validação à verificação’, in: Congresso Brasileiro de Patologia Clinica Medicina Laboratorial, Florianópolis, SC: SBPCML 52 (2018): 1-100. 
  11. Britannica: Mikhail Gorbatschev (2019). 
  12. Britannica: The Gorbachev era: perestroika and glasnost (2019). 
  13. Britannica. Spectrochemical analysis. Chemistry (2019). 
  14. Chemistry LibreTexts. Spectrophotometry (2019). 
  15. Clinical Laboratory Compliance: Something Old, Something New Melissa Scott, BS, CHC, CPC, Dinh Nguyen, MT(ASCP), CHC (Sinaiko Healthcare Consulting, Los Angeles, CA) LABMEDICINE j 40.7 (2009). 
  16. Coomer JM., et al. “To Democracy Through Anocracy”. Democracy and Society 13.1 (2016). 
  17. Dalbello A and Nesberg N. Smoothing Workflow and Reducing Errors in Specimen Processing An Interview with Albert Dalbello, Jr. and Linda Nesberg (2019). 
  18. Dias J. Why Everyone Loves Yuri Gagarin, the First Human to Reach Space (2019). 
  19. Dybkaer R. Accreditation of medical laboratories using ISO 15189 (2003). 
  20. Edimburgh Instruments. What is a Spectrometr? (2019).
  21. Grimm E and Astion M. “Organizing specimen processing for high quality and efficiency: An interview with Linda Nesberg”. Clinical Laboratory News 36.10 (2010): 12-13. 
  22. History. Perrestroilka (2019). 
  23. IFCC. The Principles of External Quality Assurance (2019). 
  24. Kawado M., et al. “A comparison of error detection rates between the reading aloud method and the double data entry method”. Controlled Clinical Trials 24 (2003): 560-569.
  25. Keim B. How Strobe Lights Cause Seizures (2020). 
  26. Lab tests Blog. Laboratory Quality Control The importance of quality control in laboratory testing (2011). 
  27. Lab tests Blog. Laboratory Quality Control What is laboratory quality control? (2012). 
  28. Lemo. Michail Gorbatschow geb (1931). 
  29. Louis Rosenfeld Clinical Chemistry Since 1800: Growth and Development Clinical Chemistry 48.1 (2002): 186-197.
  30. Luisane V. ‘Protocolo STARD’, in: Congresso Brasileiro de Patologia Clinica Medicina Laboratorial,Florianópolis, SC: SBPCML (2018): 1-27. 
  31. Luisane V., et al.  ‘Validação de métodos laboratoriais quantitativos’, in: Congresso Brasileiro de Patologia Clinica Medicina Laboratorial 52 (2018): 1-193. 
  32. Malawi L. Instrument / method validation (2019). 
  33. Menon PK. Effect of Artificial Intelligence in the Clinical Laboratory (2019). 
  34. Office of The historian. The Collapse of the Soviet Union (2019). 
  35. Oliveira CA de and Mende ME.  Gestão da fase analítica do laboratório: como assegurar a qualidade na prática. Rio de Janeiro, RJ: ControlLab (Como assegurar a qualidade na prática; v.1) (2010). 
  36. Oliveira D. ‘Validação de métodos qualitativos princípios básicos – As Orientações do CLSI EP12A2 Protocolo do usuário para avaliação do desempenho de teste qualitativo’, in: Congresso Brasileiro de Patologia Clinica Medicina Laboratorial, 52. Florianópolis, SC: SBPCML (2018): 1-34. 
  37. Randox. Importance of External Qualit Assessment (EQA) (2019). 
  38. Reason J. “Human error: models and management”. British Medical Journal 320 (2000): 768-770.
  39. Redd NT. SPACE.COM. Yuri Gagarin: First Man in Space (2018).  
  40. Rosenfeld L. “Clinical Chemistry Since 1800: Growth and Development”. Clinical Chemistry 48.1 (2002): 186-197.
  41. Sanches C. Validação de sistemas garante qualidade e segurança aos pacientes, Lab Network (2017). 
  42. Sandle N. “The management of external quality assurance”. Journal of Clinical Pathology 58 (2005): 141-144. 
  43. Schroeder T. The difference between callibrating and validating equipment (2018). 
  44. Scott M and Nguyen. Clinical Laboratory Compliance: Something Old, Something New (2009): 428-435.
  45. Teuscher N. What is GLP 9Good Laboratory Practice)? (2003).
  46. The Cold War Museum. Glasnost and Perestroika (2019). 
  47. Tieman BF. The role of lab automation in reducing diagnostic errors (2019). 
  48. Verdonck K., et al. “The Art of Writing and Implementing Standard Operating Procedures (SOPs) for Laboratories in Low-Resource Settings: Review of Guidelines and Best Practices. PLOS Neglected Tropical Diseases”. PLOS Neglected Tropical Diseases 10.11 (2019). 
  49. WHO. Word Health Organization. Good Laboratory Practce (GLP). Second Edition (2009). 
  50. WHO. World Health Organisation. Laboratory Stepwise Implementaton Tool (2015). 
  51. WHO. World Heath Organisation. Guidelines on Validation (2016). 
  52. World. Fall of Berlin Wall: How reshaped the modern world (1989). 
  53. Rosenfeld L. “Clinical Chemistry Since 1800: Growth and Development”. Clinical Chemistry 48.1 (2002):186-197.
  54. Sanches C. Validação de sistemas garante qualidade e segurança aos pacientes, LabNetwork (2017). 
  55. Sandle N. “The management of external quality assurance”. Journal of Clinical Pathology 58 (2005): 141-144. 
  56. Schroeder T. The difference between callibrating and validating equipment (2018). 
  57. Scott M Nguyen. Clinical Laboratory Compliance: Something Old, Something New. DOI: 10.1309/LM6EXL41OZEVFDXJ. Labmedicine, V. 40 N7 (2009): 428-435
  58. Teuscher N. What is GLP (Good Laboratory Practice)?  (2003).
  59. The Cold War Museum. Glasnost and Perestroika (2019). 
  60. Tieman BF. The role of lab automation in reducing diagnostic errors (2019). 
  61. Verdonck K., et al. “The Art of Writing and Implementing Standard Operating Procedures (SOPs) for Laboratories in Low-Resource Settings: Review of Guidelines and Best Practices. PLOS Neglected Tropical Diseases”. PLOS Neglected Tropical Diseases 10.11 (2019).
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Citation

Citation: Victor Lage de Araujo. “Analytical Variables in the Clinical Laboratory". Acta Scientific Microbiology 3.2 (2020): 01-09.



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