Acta Scientific Microbiology (ASMI) (ISSN: 2581-3226)

Research Article Volume 3 Issue 4

An Update on Aetiopathogenesis and Management of Japanese Encephalitis - A Systematic Review

Kulvinder Kochar Kaur1*, Gautam Allahbadia2 and Mandeep Singh3*

1Scientific Director, Dr Kulvinder Kaur Centre for Human Reproduction, Punjab, India
2Rotunda-A Centre for Human Reproduction, Mumbai, India
3Consultant Neurologist, Swami Satyanand Hospital, Jalandhar, Punjab, India

*Corresponding Author: Kulvinder Kochar Kaur, Scientific Director, Dr Kulvinder Kaur Centre for Human Reproduction, Punjab, India.

Received: November 06, 2018; Published: March 24, 2020

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Abstract

  A systematic review was carried out regarding the aetiopathogenesis of Japanese encephalitis along with its management using the pubmed search engine for MeSH terms like Japanese encephalitis, Japanese encephalitis virus; epidemiology; treatment ;vaccines for this systematic review from 1955 till date in 2020. We found a total of 6817 articles out of which we selected 50 articles for this systematic review. No meta-analysis was done. JEV and West Nile virus (WNV) are the most common encephalitic Flaviviruses. The family of Flaviviridae contains >70 members which were initially separated on the basis of cross reactivity of the antibodies they induce. Initial evaluations with polyclonal antisera into 7 subgroups, known as serocomplexes. Members of the same serocomplex are defined by the cross neutralization of the antibodies they induce. JEV and WNV belong to the same JEV serocomplex in combination with other viruses like Murray Valley encephalitic virus (MVEV), St Louis encephalitic virus (SLEV), as well as Usutu virus (USUV). Both JEV and WNV share certain ecological similarities since they maintain an enzootic transmission cycle with various bird families as natural reservoirs and mosquitoes of the Culex species as main vectors. Nonspecific treatment is available till date despite the global importance and severity of presentation causing mortality or lot of life long sequelae. Here we have tried to detail how to manage a case of acute encephalitis having a differential diagnosis of Japanese encephalitis once out of the critical stage. Role of innovative drugs that are investigational as well as orlistat is elaborated as well as different vaccines and cross reactivity of JEV antibodies with Zika virus, WNV as well as cost effectiveness of JE vaccine.

Keywords: Flaviviruses; Japanese Encephalitis; JEV; Acute Encephalitis; MRI; Orlistat

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Citation

Citation: Kulvinder Kochar Kaur., et al.“An Update on Aetiopathogenesis and Management of Japanese Encephalitis - A Systematic Review". Acta Scientific Microbiology 3.4 (2020): 176-184.



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