Acta Scientific Microbiology

Research ArticleVolume 1 Issue 8

Clinical Effect of Combined Antiretroviral Therapy (CART) on Lipid Profile and Some Atherogenic Indices of HIV Patients in Niger Delta Region

Azounwu Obioma1*, Ihua Nnenna2 and Ibioku Elekima3

1Department of Medical Laboratory Science, Medical Microbiology/Virology/Parasitology Unit, Rivers State University, Port Harcourt, Nigeria
2Department of Medical Laboratory Science, Haematology and Blood Transfusion Unit, Rivers State University, Port Harcourt, Nigeria
3Department of Medical Laboratory Science, Chemical Pathology Unit, Rivers State University, Port Harcourt, Nigeria

*Corresponding Author: Azuonwu Obioma, Department of Medical Laboratory Science, Medical Microbiology/Virology/Parasitology Unit, Rivers State University, Port Harcourt, Nigeria.

Received: July 04, 2018; Published: July 23, 2018

Citation: Azounwu Obioma.,et al. “Clinical Effect of Combined Antiretroviral Therapy (CART) on Lipid Profile and Some Atherogenic Indices of HIV Patients in Niger Delta Region”. Acta Scientific Microbiology 1.8 (2018).

Abstract

Background: The effect of Combined Antiretroviral Therapy (CART) on lipid profile and some atherogenic indices (including Castelli Risk) of HIV Patients attending Tertiary Health Facilities in Niger Delta Region, Nigeria were laboratory based assay was evaluated.

Research Design and Method: A cross sectional research design was explored to recruit a total of 199 HIV positive patients already on combined antiretroviral therapy (CART) for a period of 1- 16 years within the age range of 20 - 67 years for this study. Out of which 133 subjects were females and 66 were males respectively. Lipid parameters and some atherogenic indices were analysed using Randox Diagnostics kits, United Kingdom.

Results: The results obtained from this study when female HIV patients were considered, indicated significantly higher values in Triglyceride (TG) and Very Low Density Lipoprotein Cholesterol (VLDL) as the duration (in years) of therapy were increased. TG had values of 1.36 ± 0.26, 1.40 ± 0.47, 1.43 ± 0.36 and 2.24 ± 1.66 for different exposure of 1 - 4 years, 5 - 8 years, 9 - 12 years and 13 - 16 years respectively. Also, VLDL-C had values of 0.61 ± 0.12, 0.64 ± 0.21, 0.63 ± 0.16 and 1.02 ± 0.75 for different exposure of 1 - 4 years, 5 - 8 years, 9 - 12 years and 13 - 16 years respectively. In the analysis of variance for both TG and VLDL-C, significantly higher values were seen in TG of 13-16 years of exposure to CART compared with 1 - 4 years of exposure to CART. In addition, significantly higher values were seen in TG of 13 - 16 years of exposure to CART compared with 5 - 8 years as well as 9 - 12 years of exposure to CART. However, no significant differences were seen when duration 5 - 8 years was compared with 9 - 12 years of exposure respectively. However, when male subjects were considered, no significant differences were seen in all the lipid parameters and atherogenic indices considered. Finally, when male and female subjects using CART were compared, no significant differences were seen in all the lipid parameters and atherogenic indices considered. The increased lipid fractions especially TG and VLDL could induce increased risk of cardiovascular disease through the formation of atherosclerotic plaques

Conclusion: Therefore, it is strongly important that HIV patients on CART be monitored carefully especially in developing countries like Africa where access to complete or good health facility is of great challenge

Keywords: CART; HIV-Patients; Lipid Profile; Atherogenic Indices; Risk Factors

Copyright: © 2018 Azounwu Obioma.,et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Member In






News and Events

  • Submission Timeline
    Last date for submission of articles is June 30, 2019.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Papers of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US