Acta Scientific Microbiology

EditorialVolume 1 Issue 4

Bacterial Membrane Vesicles: New Therapeutic Prospectives

Cinzia Giagulli*

Section of Microbiology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy

*Corresponding Author: Cinzia Giagulli, Section of Microbiology, Department of Molecular and Translational Medicine, School of Medicine, University of Brescia, Brescia, Italy.

Received: February 19, 2018; Published: March 01, 2018

DOI: 10.31080/ASMI.2018.01.0030

Citation: Cinzia Giagulli. “Bacterial Membrane Vesicles: New Therapeutic Prospectives”. Acta Scientific Microbiology 1.4 (2018).


  1. Jung AL., et al . “Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages”. Journal of Visualized Experi - ments (2017): 120.
  2. Nicholas A., et al . “Clostridium difficile-derived membrane vesicles induce the expression of pro-inflammatory cyto - kine genes and cytotoxicity in colonic epithelial cells in vi- tro”. Microbial Pathogenesis 107 (2017): 6-11.
  3. Ho MH., et al . “Characterization of Innate Immune Respons - es of Human Endothelial Cells Induced by Porphyromo - nas gingivalis and Their Derived Outer Membrane Vesicles”. Frontiers in Cellular and Infection Microbiology 6 (2016): 139.
  4. Zariri A., et al . “Meningococcal Outer Membrane Vesicle Composition-Dependent Activation of the Innate Immune Response”. Infection and Immunity 84.10 (2016): 3024- 3033.
  5. Jeon H., et al . “Variation among Staphylococcus aureus membrane vesicle proteomes affects cytotoxicity of host cells”. Microbial Pathogenesis 93 (2016): 185-193.
  6. Luan L., et al . “Comparative Transcriptome Profiles of Hu - man Blood in Response to the Toll-like Receptor 4 Ligands Lipopolysaccharide and Monophosphoryl Lipid A”. Scientific Reports 7 (2017): 40050.
  7. Malgorzata-Miller G., et al . “Bartonella quintana lipopoly - saccharide (LPS): structure and characteristics of a potent TLR4 antagonist for in-vitro and in-vivo applications”. Sci - entific Reports 6 (2016): 34221.
  8. Chatterjee D., et al . “Vibrio cholerae O395 outer membrane vesicles modulate intestinal epithelial cells in a NOD1 pro- tein-dependent manner and induce dendritic cell-mediated Th2/Th17 cell responses”. Journal of Biological Chemistry 288.6 (2013): 4299-4309.
  9. Davitt C.J., et al . “Naturally-derived bacterial nano-particles engage diverse innate receptors, driving the activation of dendritic cells and leading to the establishment of potent adaptive immune responses”. Journal of Immunology 196.1 (2016): 11-76.
  10. Næss LM., et al . “Human T-cell responses after vaccination with the Norwegian group B meningococcal outer membrane vesicle vaccine”. Infection and Immunity 66.3 (1998): 959- 965.
  11. Rosenthal JA., et al . “Mechanistic insight into the T(H)1-biased immune response to recombinant subunit vaccines delivered by probiotic bacteria-derived outer membrane vesicles”. PLoS ONE 9.11 (2014): e112802.
  12. Raeven RH., et al . “Immunoproteomic profiling of Bordetella pertussis outer membrane vesicle vaccine reveals broad and balanced humoral immunogenicity”. Journal of Proteome Re - search 14.7 (2015): 2929-2942.
  13. Bottero D., et al . “Characterization of the immune response induced by pertussis OMVs-based vaccine”. Vaccine 34.28 (2016): 3303-3309.
  14. Gaillard ME., et al . “Acellular pertussis vaccine based on outer membrane vesicles capable of conferring both long-lasting immunity and protection against different strain genotypes”. Vaccine 32.8 (2014): 931-937.
  15. Huang W., et al . “Immunization against multidrug-resis - tant Acinetobacter baumannii effectively protects mice in both pneumonia and sepsis models”. PLoS ONE 9.6 (2014): e100727.
  16. Choi SJ., et al . “Active immunization with extracellular vesi - cles derived from Staphylococcus aureus effectively protects against staphylococcal lung infections, mainly via Th1 cell- mediated immunity”. PLoS ONE 10.9 (2015): e0136021.
  17. Daum RS., et al . “Progress toward a Staphylococcus aureus vaccine”. Clinical Infectious Diseases 54.4 (2012): 560-567.
  18. Van der Pol L., et al . “Outer membrane vesicles as platform vaccine technology”. Biotechnology Journal 10.11 (2015): 1689-1706.

Copyright: © 2018 Cinzia Giagulli. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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