KKH Akhmedov1*, EKH Boltaev1, AN Meliboboev1 and ZH Surabova2
1Termez Branch of Tashkent Medical Academy, Department of Normal Physiology,
Pathological Physiology and Hygiene, Termez, Uzbekistan
2Termez Branch of Tashkent Medical Academy, 3rd Year Student in the Direction of
"Pediatrics", Termez, Uzbekistan
*Corresponding Author: Anubha Bajaj, Department of Histopathology, Panjab University/A.B. Diagnostics, India.
Received: May 09, 2022; Published: July 04, 2022
Relevance of the study: From 15 to 30% of people on Earth suffer from liver disease. The leading place is occupied by cholelithiasis, which will account for 10-15% of cases in the adult population of Europe and America [3]. One of the most difficult problems in abdominal surgery is the diagnosis and treatment of cholestasis. The relevance of the problem lies in the still high lethality, among patients with mechanical jaundice of non-tumor genesis it is 5.6-6.3%.
Objective of the study: To assess the activity of catalase (AOZ) in homogenates of internal organs in the dynamics of extrahepatic ecxperimental cholestasis.
Material and Methods: The experiments were conducted on 69 white mongrel rats-males of a mixed population with an initial mass of 180-200 grams, contained in the laboratory diet in the conditions of the vivarium.Outcomes: A study of catalase activity in a control group of animals showed a tendency to increase its activity in all studied tissues for 1-3 days of the experiment. At the same time, in rats with extrahepatic cholestasis, it changed more pronouncedly.
Conclusion: Consequently, changes in catalase activity in homogenates of the liver, kidneys, pancreas, and small intestine showed less variability.
Keywords: Cholestasis; Catalase Activity; Experiment; Obturation of Bile Ducts
Citation: KH Akhmedov., et al. “Catalase Activity in the Homogenates of Internal Organs in the Dynamics of Extrahepatic Experimental Cholestasis" Acta Scientific Gastrointestinal Disorders 5.8 (2022): 22-25.
Copyright: © 2022 KH Akhmedov., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.