KKH Akhmedov¹*, EKH Boltaev¹, AN Meliboboev¹ and ZH Surabova²

¹Ph D Associate Professor, Head of the Department of Normal Physiology, Pathological Physiology and Hygiene of the Termez Branch of the Tashkent Medical Academy, Uzbekistan
²3^rd year student of the Faculty of General Medicine, direction "Pediatrics" of the Termez branch of the Tashkent Medical Academy, Uzbekistan
³2^nd year student of the Faculty of General Medicine, direction "General Medicine” of the Termez branch of the Tashkent Medical Academy, Uzbekistan

*Corresponding Author: KH Akhmedov, Ph D Associate Professor, Head of the Department of Normal Physiology, Pathological Physiology and Hygiene of the Termez Branch of the Tashkent Medical Academy, Uzbekistan.

Received: May 09, 2022; Published: July 04, 2022

Abstract

Relevance of the study: The problem of effective treatment of patients with mechanical jaundice remains relevant, despite the impressive results of biliary surgery. The main cause of mortality in patients with mechanical jaundice of benign genesis is the progression of liver failure after performing surgery on the biliary tract [3].

Objective of the study: To determine the features of the blood velocity of animals in the dynamics of experimental cholestasis.

Material and Methods: The experiments were conducted on 69 white mongrel rats-males of a mixed population with an initial mass of 180-200 grams, contained in the laboratory diet in the conditions of the vivarium.

Outcomes:In the experimental group of animals, we revealed an even greater increase in blood hyperviscosity, while the shear rate increased slightly relative to the values of the previous study period. Thus, the shear rate was at applied pressure values of 8-, 12- and 16-mm. water station below the value of intact rats by 60; 80.56 and 73.5%, respectively.

Conclusion: The results of the studies indicate that the violation of the rheological properties of the blood as a result of ligation of the common bile duct is transient. These results to a certain extent explain the disturbances in the microcirculation system of the organs studied.

Keywords:Experiment; Cholestasis; Blood Flow Rate; Obturation of the Bile Ducts

References

1. Akhmedov KKh and Yuldashev NM. “The main mechanisms of development of multiple organ failure in the modeling of acute obturation of the biliary tract”. Medical Journal of Uzbekistan 4 (2010): 87.
2. Zufarov KA and Sadriddinov AF. “Sclerotic changes in the liver in experimental cholestasis and their reversibility after restoration of bile outflow”. Bulletin of Experimental Biology and Medicine 7 (1986): 105-108.
3. Magomedov MM., et al. “Diagnostics and treatment of mechanical jaundice syndrome”. International Research Journal 106 (2021).
4. Styazhkina SN., et al. “Actual problems of mechanical jaundice in surgery”. International Journal of Applied and Fundamental Research3 (2016): 427-430.
5. Udovichenko VI. “Improved Copeli viscometer for determining viscosity in small blood samples under thermostable conditions”. Pathological Physiology and Experimental Therapy 1 (1978): 73-75.
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Citation

Citation: KH Akhmedov., et al. “Features of Rheological Properties of Animal Blood in the Dynamics of Experimental Cholestasis" Acta Scientific Gastrointestinal Disorders 5.8 (2022): 18-21.

Copyright

Copyright: © 2022 KH Akhmedov., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.