Acta Scientific Gastrointestinal Disorders (ISSN: 2582-1091)

Research Article Volume 3 Issue 4

Association Between Overlapping Syndromes and Renal Lithiasis in Patients with Inflammatory Bowel Disease

Dídia Bismara Cury1*, Ana Camila Michelletti2, Rogério A3, Elsa Alidia Cury Petry Gonçalves4 and Nestor Schor5

1Inflammatory Bowel Disease Center, Scope Clinic, Campo Grande, MS, Brazil
2Federal University of Mato Grosso do Sul, Chemistry Program, Campo Grande, MS, Brazil
3Biostatistcs, UNESP, Botucatu, São Paulo, SP, Brazil
4Federal University of Mato Grosso do Sul, Faculty of Medicine, Clinical Pharmacology, Campo Grande, MS, Brazil
5Federal University of Sao Paulo, Nephrology Division, Sao Paulo, SP, Brazil

*Corresponding Author: Dídia Bismara Cury, Inflammatory Bowel Disease Center, Scope Clinic, Campo Grande, MS, Brazil.

Received: January 18, 2020; Published: March 30, 2020

×

Abstract

Background: Irritable bowel syndrome (IBS) is considered a motor disorder due to the absence of a specific organic disease. The diagnosis of IBS is based on clinical criteria, including the Rome III criteria. Patients with IBS can have overlapping conditions, such as lactose intolerance (generally underdiagnosed) and inflammatory bowel disease (Crohn's disease or idiopathic ulcerative colitis). All of these lead to diarrhea, which is a risk factor for renal lithiasis. The objective of this study was to evaluate the combined presence of lactase intolerance and IBS as a risk factor for renal lithiasis in patients with inflammatory bowel disease, as well as the role of diagnostic tests in preventing renal complications of lithiasis.

Methods: We analyzed the electronic medical records of 168 patients with inflammatory bowel disease treated between 2009 and 2010 (for 24 months) at the Inflammatory Bowel Disease Center of the Scope Clinic, located in the city of Campo Grande, Brazil.

Results: Ulcerative colitis was diagnosed in 75 patients, of whom 29 were diagnosed with lactose intolerance, without an increased risk for renal lithiasis, and 24 had IBS, which was found to increase the risk for the formation of renal calculi (OR = 3.7; 95% CI: 1.2–11; P = 0.03). Crohn's disease was diagnosed in 93 patients, of whom 25 had lactose intolerance and 21 had IBS. Lactose intolerance was directly related to the underlying disease (OR = 4.0; 95% CI: 1.6–9; P = 0.003). Crohn's disease correlated strongly with IBS; of the 93 Crohn’s disease patients, 40 also had IBS (OR = 4.0; 95% CI: 1.6–9; P = 0.003). Ulcerative colitis, especially when active, was found to increase the risk of renal lithiasis.

Conclusions: Patients with diseases that are accompanied by diarrhea should be screened for renal lithiasis in order to prevent renal complications.

Keywords: Irritable Bowel Syndrome; Kidney Calculi; Malabsorption Syndromes; Lactose Intolerance

×

References

  1. Sorouri M., et al. “Functional bowel disorders in Iranian population using Rome III criteria”. Saudi Journal of Gastroenterology 16.3 (2010): 154-160.
  2. Everhart JE and Renault PF. “Irritable bowel syndrome in office-based practice in the United States”. Gastroenterology 100.4 (1991): 998-1005.
  3. Schuster MM. “Diagnostic evaluation of the irritable bowel syndrome”. Gastroenterology Clinics of North America 20.2 (1991): 269-278.
  4. Levy RL., et al. “Costs of care for irritable bowel syndrome patients in a health maintenance organization”. American Journal of Gastroenterology 96.11 (2011): 3122-3129.
  5. Levy RL., et al. “Irritable bowel syndrome in twins: heredity and social learning both contribute to etiology”. Gastroenterology 121.4 (2001): 799-804.
  6. Heitkemper M., et al. “Autonomic nervous system function in women with irritable bowel syndrome”. Digestive Diseases and Sciences 46.6 (2001): 1276-1284.
  7. Halvorson HA., et al. “Postinfectious irritable bowel syndrome--a meta-analysis”. American Journal of Gastroenterology 101.8 (2006): 1894-1899; quiz 942.
  8. Ginsburg PM and Bayless TM. “How can IBD be distinguished from IBS?” Inflammatory Bowel Disease 14 (2008): S152-154.
  9. Bolin T. “IBS or intolerance?” Australian Family Physician 38.12 (2009): 962-965.
  10. Lomer MC., et al. “Review article: lactose intolerance in clinical practice--myths and realities”. Alimentary Pharmacology and Therapeutics 27.2 (2008): 93-103.
  11. Cremon C., et al. “Intestinal dysbiosis in irritable bowel syndrome: etiological factor or epiphenomenon?” Expert Review of Molecular Diagnostics 10.4 (2010): 389-393.
  12. Park JH., et al. “The Relationship between Small-Intestinal Bacterial Overgrowth and Intestinal Permeability in Patients with Irritable Bowel Syndrome”. Gut Liver 3.3 (2009): 174-179.
  13. Vesa TH., et al. “Role of irritable bowel syndrome in subjective lactose intolerance”. The American Journal of Clinical Nutrition 67.4 (1998): 710-715.
×

Citation

Citation: Didia Bismara Cury., et al. “Association Between Overlapping Syndromes and Renal Lithiasis in Patients with Inflammatory Bowel Disease”. Acta Scientific Gastrointestinal Disorders 3.3 (2020): 01-04.



Member In





News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 15, 2020.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US