Acta Scientific Gastrointestinal Disorders (ISSN: 2582-1091)

Research Article Volume 3 Issue 4

Association Between Overlapping Syndromes and Renal Lithiasis in Patients with Inflammatory Bowel Disease

Dídia Bismara Cury1*, Ana Camila Michelletti2, Rogério A3, Elsa Alidia Cury Petry Gonçalves4 and Nestor Schor5

1Inflammatory Bowel Disease Center, Scope Clinic, Campo Grande, MS, Brazil
2Federal University of Mato Grosso do Sul, Chemistry Program, Campo Grande, MS, Brazil
3Biostatistcs, UNESP, Botucatu, São Paulo, SP, Brazil
4Federal University of Mato Grosso do Sul, Faculty of Medicine, Clinical Pharmacology, Campo Grande, MS, Brazil
5Federal University of Sao Paulo, Nephrology Division, Sao Paulo, SP, Brazil

*Corresponding Author: Dídia Bismara Cury, Inflammatory Bowel Disease Center, Scope Clinic, Campo Grande, MS, Brazil.

Received: January 18, 2020; Published: March 30, 2020



Background: Irritable bowel syndrome (IBS) is considered a motor disorder due to the absence of a specific organic disease. The diagnosis of IBS is based on clinical criteria, including the Rome III criteria. Patients with IBS can have overlapping conditions, such as lactose intolerance (generally underdiagnosed) and inflammatory bowel disease (Crohn's disease or idiopathic ulcerative colitis). All of these lead to diarrhea, which is a risk factor for renal lithiasis. The objective of this study was to evaluate the combined presence of lactase intolerance and IBS as a risk factor for renal lithiasis in patients with inflammatory bowel disease, as well as the role of diagnostic tests in preventing renal complications of lithiasis.

Methods: We analyzed the electronic medical records of 168 patients with inflammatory bowel disease treated between 2009 and 2010 (for 24 months) at the Inflammatory Bowel Disease Center of the Scope Clinic, located in the city of Campo Grande, Brazil.

Results: Ulcerative colitis was diagnosed in 75 patients, of whom 29 were diagnosed with lactose intolerance, without an increased risk for renal lithiasis, and 24 had IBS, which was found to increase the risk for the formation of renal calculi (OR = 3.7; 95% CI: 1.2–11; P = 0.03). Crohn's disease was diagnosed in 93 patients, of whom 25 had lactose intolerance and 21 had IBS. Lactose intolerance was directly related to the underlying disease (OR = 4.0; 95% CI: 1.6–9; P = 0.003). Crohn's disease correlated strongly with IBS; of the 93 Crohn’s disease patients, 40 also had IBS (OR = 4.0; 95% CI: 1.6–9; P = 0.003). Ulcerative colitis, especially when active, was found to increase the risk of renal lithiasis.

Conclusions: Patients with diseases that are accompanied by diarrhea should be screened for renal lithiasis in order to prevent renal complications.

Keywords: Irritable Bowel Syndrome; Kidney Calculi; Malabsorption Syndromes; Lactose Intolerance



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Citation: Didia Bismara Cury., et al. “Association Between Overlapping Syndromes and Renal Lithiasis in Patients with Inflammatory Bowel Disease”. Acta Scientific Gastrointestinal Disorders 3.3 (2020): 01-04.


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