Arun Kumar Das1*, Md. Abdus Sattar2, SM Sumsuzzoha3 and Shaila Zaman4
1Junior Consultant, Department of Skin and Venereology, 250 Beded General Hospital, Meherpur, Bangladesh 2Assistant Professor, Department of Skin and Venereology, Kushtia Medical College, Khshtia, Bangladesh 3Assistant Professor, Department of Dermatology, Naogaon Medical College, Naogaon, Bangladesh 4Junior Consultant, Department of Skin and Venereology, Joypurhat District Hospital, Joypurhat, Bangladesh
*Corresponding Author: Arun Kumar Das, Junior Consultant, Department of Skin and Venereology, 250 Beded General Hospital, Meherpur, Bangladesh.
Received: June 05, 2023; Published: June 22, 2023
Background: In limited lesions of tinea versicolor topical drugs are found as effective; but in extensive cases, systemic drugs are more suitable. Both oral fluconazole and ketoconazole are usually used in Bangladesh in the management of tinea versicolor. But we have very limited comparative information regarding the efficacies of fluconazole and ketoconazole in treating tinea versicolor respectively.
Aim of the Study: The aim of this study was to compare the efficacies of fluconazole and ketoconazole in treating tinea versicolor.
Methods: This comparative observational study was conducted in the department of Skin and Venereology, 250 Baded General Hospital, Meherpur, Bangladesh during the period from May 2022 to April 2023. In total 70 patients with tinea versicolor from several age groups of either gender were enrolled as the study subjects who had continued up to the end of the full tenure of this intervention. All the patients were randomly divided into equal two groups. Patients of group 1(n = 35), received 300 mg fluconazole as a single dose and repeated weekly for 2 weeks and patients of group 2(n = 35), received 400 mg ketoconazole as a single dose and repeated weekly for 2 weeks. Diagnosis of tinea versicolor was made clinically by direct KOH preparation.
Results: In this study, the male-female ratio of the participants was 1.1:1. The mean age of the respondents of group 1 was 31.37 ± 3.28 years which was 30.44 ± 2.88 years in group 2. The mean duration of suffering (In year) was 4.28 ± 0.69 years in group 1 which was found as 4.74 ± 0.54 in group 2. In group 1, at one months’ follow up, in assessing the clinical responses, cured, improved and unchanged cases were found as 66%, 26% and 9% respectively which statuses were found in 57%, 26% and 17% cases respectively in group 2. In assessing the mycological response at 1-month follow-up, in group 1, mycological eradication was found in 71% cases which was found among 60% cases in group 2.
Conclusion: Although, in this current study, in treating tinea versicolor, we found some superiority of fluconazole regarding the efficacy over ketoconazole, but the difference was not remarkable. Both the antifungal azole agents were found as well tolerated.
Keywords: Tinea; Versicolor; Fluconazole; Ketoconazole; Azole; Efficacy
Citation: Arun Kumar Das., et al. “A Comparative Study Between Efficacies of Fluconazole and Ketoconazole in Tinea Versicolor". Acta Scientific Dermatology and Venereology 1.1 (2023): 18-22.
Copyright: © 2023 Arun Kumar Das., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.