Acta Scientific Dental Sciences (ISSN: 2581-4893)

Mini Review Volume 4 Issue 1

The Effect of Metastasis on Treatment and Prognosis of Oral Cancer: Short Review

Moustafa Elhousiny*

PHD, Research Assistant, College of Medicine and Dentistry, James Cook University, Cairns, Australia

*Corresponding Author: Moustafa Elhousiny, PHD, Research Assistant, College of Medicine and Dentistry, James Cook University, Cairns, Australia.

Received: December 09, 2019; Published: December 31, 2019

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Abstract

  Metastasis is the leading cause of fatality in 90% of cancers, and approximately 60% of all cancer cases will have either regional or distant metastasis at initial diagnosis. Global data shows that survival rates drop significantly with the advance of disease stage and metastatic activity; therefore, patients with localised disease have a far better prognosis than those with disseminated tumours. In this aspect, oral squamous-cell carcinoma (OSCC) is locally invasive neoplasms. Both cancers are considered the worst prognosis cancers with an overall survival rate of 50% or slightly higher. In this review, we summarise the latest data in the literature about the impact of metastasis on oral cancer prognosis and the choice of treatment, emphasising the urgent need for reliable markers for the early detection and prevention of oral neoplasms to improve the patient outcome.

Keywords: Metastasis; Oral Squamous Cell Carcinoma; Oral Cancer; Prognosis; Treatment

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References

  1. Ferlay J., et al. “Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008”. International Journal of Cancer 127.12 (2010): 2893-2917.
  2. Warnakulasuriya S. “Global epidemiology of oral and oropharyngeal cancer”. Oral Oncology 45.4 (2009): 309-316.
  3. Rao S., et al. “Epidemiology of oral cancer in Asia in the past decade-an update (2000-2012)”. Asian Pacific Journal of Cancer Prevention 14.10 (2013): 5567-5577.
  4. Shah I., et al. “Clinical stage of oral cancer patients at the time of initial diagnosis”. Journal of Ayub Medical College Abbottabad 22.3 (2010): 61-63.
  5. Pulte D and Brenner H. “Changes in survival in head and neck cancers in the late 20th and early 21st century: a period analysis”. The Oncologist 15.9 (2010): 994-1001.
  6. Van der Waal I. “Are we able to reduce the mortality and morbidity of oral cancer; some considerations”. Medicina Oral, Patologia Oral Y Cirugia Bucal 18.1 (2013): 33.
  7. Centelles P., et al. “Timing of oral cancer diagnosis: Implications for prognosis and survival”. Oral Cancer Ogbureke (2012):173-188. 
  8. Chen G and Chen C. “A study on survival rates of oral squamous cell carcinoma]”. The Kaohsiung Journal of Medical Sciences 12.6 (1996): 317-325.
  9. Dünne A., et al. “Meta-analysis of the prognostic significance of perinodal spread in head and neck squamous cell carcinomas (HNSCC) patients”. European Journal of Cancer 42.12 (2006):1863-1868.
  10. Jones A. “Prognosis in mouth cancer: tumor factors”. European Journal of Cancer Part B: Oral Oncology 30.1 (1994): 8-15. 
  11. Tankéré F., et al. “Prognostic value of lymph node involvement in oral cancers: a study of 137 cases”. The Laryngoscope 110.12 (2000): 2061-2065.
  12. Woolgar J., et al. “Survival and patterns of recurrence in 200 oral cancer patients treated by radical surgery and neck dissection”. Oral Oncology 35.3 (1999): 257-265.
  13. Woolgar J., et al. “Cervical lymph node metastasis in oral cancer: the importance of even microscopic extracapsular spread”. Oral Oncology 39.2 (2003): 130-137.
  14. Zou S., et al. “Relationship between extracapsular spread of cervical metastatic lymph node and cervical recurrence in oral cancer patients]”. Zhonghua Kou Qiang Yi Xue Za Zhi= Zhonghua Kouqiang Yixue Zazhi= Chinese Journal of Stomatology 42.9 (2007): 541-543.
  15. Liao C., et al. “Outcome analysis of patients with oral cavity cancer and extracapsular spread in neck lymph nodes”. International Journal of Radiation Oncology Biology Physics 81.4 (2011): 930-937.
  16. Myers JN., et al. “Extracapsular spread. A significant predictor of treatment failure in patients with squamous cell carcinoma of the tongue”. Cancer 92.12 (2001): 3030-3036.
  17. Woolgar J. “Micrometastasis in oral/oropharyngeal squamous cell carcinoma: incidence, histopathological features and clinical implications”. British Journal of Oral and Maxillofacial Surgery 37.3 (1999): 181-186.
  18. Ferlito A., et al. “The incidence of lymph node micrometastases in patients pathologically staged N0 in cancer of oral cavity and oropharynx”. Oral Oncology 38.1 (2002): 3-5.
  19. Pimenta Amaral T., et al. “Predictive factors of occult metastasis and prognosis of clinical stages I and II squamous cell carcinoma of the tongue and floor of the mouth”. Oral Oncology 40.8 (2004): 780-786.
  20. Hiratsuka H., et al. “Multivariate analysis of occult lymph node metastasis as a prognostic indicator for patients with squamous cell carcinoma of the oral cavity”. Cancer 80.3 (1997): 351-356.
  21. El-Naaj I., et al. “Incidence of oral cancer occult metastasis and survival of T1-T2N0 oral cancer patients”. Journal of Oral and Maxillofacial Surgery 69.10 (2011): 2674-2679.
  22. Goto M., et al. “Prognostic significance of late cervical metastasis and distant failure in patients with stage I and II oral tongue cancers”. Oral Oncology 41.1 (2005): 62-69.
  23. Qi-Gen F. “Occult Node Metastasis in Early Tongue Squamous Cell Carcinoma”. Anaplastology S6. 1 (2013): 2161-1173.
  24. Zhang T., et al. “Treatment of cT1N0M0 tongue cancer: outcome and prognostic parameters”. Journal of Oral and Maxillofacial Surgery 72.2 (2014): 406-414.
  25. Jang W., et al. “Treatment of patients with clinically lymph node-negative squamous cell carcinoma of the oral cavity”. Japanese Journal of Clinical Oncology 38.6 (2008): 395-401.
  26. Thiele O., et al. “The role of elective supraomohyoidal neck dissection in the treatment of early, node-negative oral squamous cell carcinoma (OSCC): a retrospective analysis of 122 cases”. Journal of Cranio-Maxillofacial Surgery 40.1 (2012): 67-70.
  27. Betka J. “Distant metastases from lip and oral cavity cancer”. ORL 63.4 (2001): 217-221.
  28. Takes R., et al. “Distant metastases from head and neck squamous cell carcinoma. Part I. Basic aspects”. Oral Oncology 48.9 (2012): 775-779.
  29. Kuperman D., et al. “Squamous cell cancer of the head and neck with distant metastasis at presentation”. Head and Neck 33.5 (2011): 714-718.
  30. De Bree R., et al. “Screening for distant metastases in patients with head and neck cancer”. The Laryngoscope 110.3 (2000): 397-401.
  31. Jäckel M and Rausch H. “Distant metastasis of squamous epithelial carcinomas of the upper aerodigestive tract. The effect of clinical tumor parameters and course of illness]”. HNO 47.1 (1999): 38-44.
  32. Garavello W., et al. “Risk factors for distant metastases in head and neck squamous cell carcinoma”. Archives of Otolaryngology--Head and Neck Surgery 132.7 (2006): 762-766.
  33. Ljumanovic R., et al. “Distant metastases in head and neck carcinoma: identification of prognostic groups with MR imaging”. European Journal of Radiology 60.1 (2006): 58-66.
  34. Leibel S., et al. “The effect of local-regional control on distant metastatic dissemination in carcinoma of the head and neck: results of an analysis from the RTOG head and neck database”. International Journal of Radiation, Oncology, Biology, Physics 21.3 (1991): 549-556.
  35. Li X., et al. “Clinicopathologic risk factors for distant metastases from head and neck squamous cell carcinomas”. European Journal of Surgical Oncology (EJSO) 35.12 (2009): 1348-1353.
  36. Sumioka S., et al. “Risk factors for distant metastasis in squamous cell carcinoma of the oral cavity”. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons 71.7 (2013): 1291-1297.
  37. Shintani S., et al. “Regional lymph node involvement affects the incidence of distant metastasis in tongue squamous cell carcinomas”. Anticancer Research 15.4 (1994): 1573-1576.
  38. Lim J., et al. “Predictive factors of isolated distant metastasis after primary definitive surgery without systemic treatment for head and neck squamouscell carcinoma”. Oral Oncology 46.7 (2010): 504-508.
  39. Shingaki S., et al. “Surgical treatment of stage I and II oral squamous cell carcinomas: analysis of causes of failure”. British Journal of Oral and Maxillofacial Surgery 33.5 (1995): 304-308.
  40. Lee D., et al. “Distant metastases and survival prediction in head and neck squamous cell carcinoma”. Otolaryngology--Head and Neck Surgery (2012).
  41. Ferlito A., et al. “Incidence and sites of distant metastases from head and neck cancer”. Oto-Rhino-Laryngology 63.4 (2001): 202-207.
  42. Genden E., et al. “Contemporary management of cancer of the oral cavity”. European Archives of Oto-Rhino-Laryngology 267.7 (2010): 1001-1017. 
  43. Wei W., et al. “Management of the N0 neck—reference or preference”. Oral Oncology 42.2 (2006): 115-122.
  44. Klingerman J., et al. “Supraomohyoid neck dissection in the treatment of T1/T2 squamous cell carcinoma of oral cavity”. The American Journal of Surgery 168 (1994): 391-394.
  45. Fakih A and Patel A. Prophylactic neck dissection in squamous cell carcinoma of oral tongue: a prospective randomized study 5.5 (1989): 327-330.
  46. Yuen A., et al. “Prospective randomized study of selective neck dissection versus observation for N0 neck of early tongue carcinoma”. Head and Neck 31.6 (2009): 765-772.
  47. Fasunla A., et al. “A meta-analysis of the randomized controlled trials on elective neck dissection versus therapeutic neck dissection in oral cavity cancers with clinically node-negative neck”. Oral Oncology 47.5 (2011): 320-324.
  48. Deng H., et al. “The treatment of oral cancer: an overview for dental professionals”. Australian Dental Journal 56.3 (2011): 244-252.
  49. Rapidis A. “Multidisciplinary Management of Oral Cavity and Maxillary Sinus Cancers”. Springer (2011): 363-380.
  50. Pignon J., et al. “Chemotherapy added to loco-regional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data”. The Lancet 355.9208 (2000): 949-955.
  51. Pignon J., et al. “Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients”. Radiotherapy and Oncology 92.1 (2009): 4-14.
  52. Ma J., et al. “Induction chemotherapy decreases the rate of distant metastasis in patients with head and neck squamous cell carcinoma but does not improve survival or loco-regional control: a meta-analysis”. Oral oncology 48.11 (2012): 1076-1084.
  53. Furness S., et al. “Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy”. Cochrane Database of Systematic Reviews (2011): 4.
  54. Zhang H., et al. “Survival outcomes of patients with advanced oral cavity squamous cell carcinoma treated with multimodal therapy: a multi-institutional analysis”. Journal of Otolaryngology-Head \and Neck Surgery 42.1 (2013): 30.
  55. Da Silva S., et al. “Recurrent oral cancer: current and emerging therapeutic approaches”. Frontiers in Pharmacology (2012): 3.
  56. Goodwin WJ. “Salvage surgery for patients with recurrent squamous cell carcinoma of the upper aerodigestive tract: when do the ends justify the means?” Laryngoscope 110.93 (2000): 1-18.
  57. Koo B., et al. “Recurrence and salvage treatment of squamous cell carcinoma of the oral cavity”. Oral Oncology 42.8 (2006): 789-794.
  58. Ord R and Blanchaert R. “Current management of oral cancer: A multidisciplinary approach”. The Journal of the American Dental Association 132.1 (2001): 19-23.
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Citation

Citation: Moustafa Elhousiny. “The Effect of Metastasis on Treatment and Prognosis of Oral Cancer: Short Review".Acta Scientific Dental Sciences 4.1 (2020): 111-116.



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