Acta Scientific Dental Sciences (ASDS)(ISSN: 2581-4893)

Research Article Volume 6 Issue 1

The Effect of Premedication with Curcumin on Post-operative Pain in Single Visit Endodontic Treatment of Acute Pulpitis in Mandibular Molars: A Randomized Controlled Trial

Mohamed Sobhy Abdelnaby1, Ghada El Hilaly Eid1* and Mohamed Ahmed El Nabarawi2

1Faculty of Dentistry, Department of Endodontics, Cairo University, Egypt
2Faculty of Pharmacy, Department of Pharmaceutics and Industrial Pharmacy, Cairo University, Egypt

*Corresponding Author: Ghada El Hilaly Eid, Faculty of Dentistry, Department of Endodontics, Cairo University, Egypt.

Received: November 19, 2021; Published: December 23, 2021

Abstract

Purpose: The purpose of this triple-blinded (patient, operator, and outcome assessor), 1:1 randomized clinical trial was comparing the effect of a single preoperative dose of Curcumin versus placebo on post-operative pain after single visit root canal treatment for symptomatic irreversible pulpitis in mandibular molars.

Methods: Forty-four patients suffering from symptomatic irreversible pulpitis of mandibular molars were randomly and equally allocated into two groups. Single oral dose of Curcumin (400 mg + 20 mg pepper) or placebo capsules was administered one hour before treatment. After inferior alveolar nerve block, root canal treatment was completed in a single visit. The need for supplemental anesthesia was recorded. Patients were instructed to score pain using visual analogue pain scale (VAS): preoperatively, immediately post-operative, 8, 12, 24 and 48 hours postoperative, as well as to state number of rescue analgesic tablets. Data were statistically analyzed; significance was set at P value ≤ 0.05.

Results: Baseline characteristics of both groups showed non-significant difference (P > .05). Curcumin group at 8, 12 and 24 hours revealed significantly less VAS values (44.2, 26.7, 19.1) than the placebo (58.5, 43.3, 30.3), respectively, (P < .05). Curcumin group significantly needed lower percentages supplemental anesthesia (27.3%) compared to placebo (68.2%), (P < 05). All patients in Curcumin group did not need rescue medication, while two patients in placebo took it.

Conclusions: Single preoperative oral dose of Curcumin proved to be an effective premedication that reduced post-operative pain as well as the need of supplemental anesthesia for patients diagnosed with symptomatic irreversible pulpitis of mandibular molars.

 

Keywords: Symptomatic Irreversible Pulpitis; Mandibular Molars; Post-operative Pain; Curcumin; Randomized Controlled Trial

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Citation

Citation: Ghada El Hilaly Eid., et al. “The Effect of Premedication with Curcumin on Post-operative Pain in Single Visit Endodontic Treatment of Acute Pulpitis in Mandibular Molars: A Randomized Controlled Trial". Acta Scientific Dental Sciences 6.1 (2022): 87-95.

Copyright

Copyright: © 2022 Ghada El Hilaly Eid., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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Impact Factor1.057

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