Acta Scientific Dental Sciences

Research ArticleVolume 2 Issue 7

Amoxicillin-Metronidazole vs Spiramycin-Metronidazole in the Treatment of Odontogenic Circumscribed Cellulitis: Randomized Clinical Trial in Odontostomatology

Bengondo Messanga Charles1, Ntep Ntep David Bienvenue1*, Bola Siafa Antoine2,Nnanga Nga Emmanuel 3 and Onana Jules1

1Odontostomatology and Maxillofacial Surgery Department, Yaounde University Teaching and Hospital Center, ‎Yaoundé‎, Cameroon
2Oto-Rhino-Laryngology Department, Yaoundé University Teaching and Hospital Center, ‎Yaoundé‎, Cameroon
3Department of Galenic Pharmacy and Pharmaceutical Legislation, University of Yaounde I, Yaoundé‎, Cameroon

*Corresponding Author: Ntep Ntep David Bienvenue, Odontostomatology and Maxillofacial Surgery Department, Yaounde University Teaching and Hospital Center, Yaounde, Cameroon.

Received: May 25, 2018; Published: June 14, 2018

Citation: Ntep Ntep David Bienvenue., et al. “Amoxicillin-Metronidazole vs Spiramycin-Metronidazole in the Treatment of Odontogenic Circumscribed Cellulitis: Randomized Clinical Trial in Odontostomatology”. Acta Scientific Dental Sciences 2.7 (2018).

Abstract

Introduction: In clinical practice, amoxicillin-metronidazole is widely used in the treatment of odontogenic infections. Therefore, this study was designed to generate data to support its use. This demonstrated the clinical efficacy of the amoxicillin-metronidazole combination compared with the spiramycin-metronidazole combination in subjects with odontogenic circumscribed cellulitis. The clinical trial was supplemented by an evaluation of the compliance and tolerability of the antibiotics under study.

Methodology: This was a randomized, parallel, comparative, double-blind clinical trial. This study evaluated the efficacy, tolerability, and compliance of amoxicillin-metronidazole and spiramycin-metronidazole combinations in adult subjects with odontogenic circumscribed cellulitis. Subjects were reassessed after three, five and seven days. At the end of the treatment, the patients were classified in (clinical success) or “failure”.

Results: The study was conducted on 81 patients in intention-to-treat analysis and 61 patients in per-protocol analysis. In intent to treat, the clinical success of amoxicillin-metronidazole, spiramycin-metronidazole combinations was greater than 90% in the treatment of serous circumscribed cellulitis. Clinical tolerance and compliance were not different from one group to another.

Conclusion: The non-inferiority of amoxicillin-metronidazole combination compared to spiramycin-metronidazole combination was demonstrated in intention-to-treat and per-protocol analysis.

Keywords: Cellulitis; Amoxicillin; Spiramycin; Metronidazole; Per-Protocol; Intent to Treat

Copyright: © 2018 Ntep Ntep David Bienvenue., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



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