Masood H Khan1*,Sadaf ghani2, Rubia sidiqui3, Md Aasadullah4 and Tooba qazi5
1,4Assistant Professor, Department of Oral Pathology/Oral Medicine, Dr ZA Dental College and Hospital AMU, Aligarh, Uttar Pradesh, India
2Assistant Professor, Department of Paedodontic, Dr ZA Dental College and Hospital AMU, Aligarh, Uttar Pradesh, India
3Assistant Professor, Department of Oral Surgery, Dr ZA Dental College and Hospital AMU, Aligarh, Uttar Pradesh, India
5Dental Graduate Student
*Corresponding Author: Masood H Khan, Assistant Professor, Department of Oral Pathology/Oral Medicine, Dr ZA Dental College and Hospital AMU, Aligarh, Uttar Pradesh, India.
Received: February 02, 2018; Published: March 26, 2018
Citation: Masood H Khan., et al. “To Study Amylase Levels in the Saliva of Khaini/Tobacco Chewers and Bidi Smokers with the Normal Controls”. Acta Scientific Dental Sciences 2.4 (2018).
Tobacco consumption is regarded as one of the most important public health problem worldwide most importantly the development of oral cancers. It is consumed in diverse forms like smoking, chewing, snuff dipping, etc. in spite of being the major indepen dent risk factor for the development of oral cancer. The use of saliva for diagnostic purpose is gaining wide momentum in recent years. It is considered as a reliable tool in hormone analysis, drug monitoring etc. Tobacco consumption has been reported to cause severe morphological and functional alterations in salivary glands. Based on these facts it could be postulated that tobacco use can adversely affect the salivary glands resulting in alteration in quality and quantity of saliva. Hence the present study is undertaken to evaluate the changes in the biochemical constituents of saliva in tobacco smokers and chewers and compare with those of healthy controls.
Materials and Method: Patients reporting to the OPD of the Department of Oral Pathology and Oral Medicine at Dr Z A Dental College, AMU Aligarh, were included in the study. The present study comprised of 150 subjects, 50 subjects had a habit of bidi (tobacco) smoking, 50 subjects had a habit of khaini (tobacco chewing) and 50 were gender and age related healthy subjects (with no smoking or chewing habit) i.e. the control group. All the subjects were male in the age group of 20 - 40 years as tobacco intake is more prevalent in the younger age group. Subjects were asked to refrain from eating, drinking or smoking one hour prior to collection of saliva. Each subject was asked to accumulate saliva in the mouth for about 2 minutes, after which he was asked to spit the accumulated saliva into a sterile plastic container. This was repeated for about 6 minutes for each subject and the unstimulated whole saliva thus collected was refrigerated at 4oC and processed within 24 hours for estimation of biochemical constituents.
Result: Salivary Amylase as calculated in smokers, chewers and controls was significantly reduced in both tobacco chewers and smokers. This could be attributed to the injury to Ductal Secretory unit caused by tobacco related toxic products or the effect of increase salivary flow with dilutional effect in tobacco users. The salivary flow rate in tobacco smokers is also found to be low. There is excess secretion of saliva in tobacco chewers as compared to smokers, as chewing may lead to hypertrophy of the masticatory muscles which may express greater salivary flow from the glands.
Keywords: Tobacco; PH; Saliva Smoking
Copyright: © 2018 Masood H Khan., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.