Assistant Professor, Department of Paediatric and Preventive Dentistry, Dr. Z.A Dental College and Hospital, AMU, Aligarh, Uttar Pradesh, India
*Corresponding Author: Akash Bhatnagar, Assistant Professor, Department of Paediatric and Preventive Dentistry, Dr. Z.A Dental College and Hospital, AMU, Aligarh, Uttar Pradesh, India.
Received: January 16, 2017; Published: February 16, 2018
Citation: Akash Bhatnagar. “New CMCR Agent: Papacarie”. Acta Scientific Dental Sciences 2.3 (2018).
Chemomechanical caries removal is a noninvasive method of caries removal using a chemical agent and hand instruments. In the current scenario, the main focus is on maximum preservation of tooth structure. CMCR is based on the concepts of minimal invasive dentistry (MID). The main objective of this method is to eliminate the infected soft dentin, leaving the affected dentin, which can be easily remineralized .
Papacarie containing papain gel is first introduced in Brazil, 2003 as CMCR agent and patented by ANVISA in Brazil. Papain gel extracted from the adult green papaya is one of the main component of this product. Chloramine and Toluidine Blue are the other two components. Papain gel acts as proteolytic enzyme on infected tissue with anti-inflammatory and bactericide characteristics. It’s main action only on infected tissue which lacks the alpha-1-antitrypsin (plasmatic protease inhibitor). So, In the absence of protease inhibitor in infected tissues allows papain gel to break and dissolution of partially degraded collagen [2,3].
Copyright: © 2018 Akash Bhatnagar. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.