Acta Scientific Cancer Biology

Review Article Volume 4 Issue 2

Sinigrin: A Cancer Preventing Agent

Meghna Garg, Anubhuti Sharma* and PK Rai

Senior Scientist (Biochemistry), ICAR-DRMR, Bharatpur, (Rajasthan), India

*Corresponding Author: Anubhuti Sharma, Senior Scientist (Biochemistry), ICAR-DRMR, Bharatpur, (Rajasthan), India.

Received: November 25, 2019; Published: January 18, 2020

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Abstract

  Various biologically active compounds present in mustard have proved as potential anti-cancerous agents. Sinigrin inhibits angiogenesis and reduces inflammation in tumors. Phenethyl isothiocyanates (PEITC) induces apoptosis in Jurkat T-lymphoma cells overexpressing the oncoprotein Bcl-2. Sulforaphane inhibits cell proliferation and metastasis, block the action of mutagens and induces apoptosis of the transformed cells. High selenium mustard can help in curing breast and prostate cancer. Mustard seeds rich diet has been shown to prevent colon, skin and cervix cancer in animal model. Benzyl isothiocyanate (BITC) suppresses pancreatic tumor growth and angiogenesis. The following review tried to throw light on the mechanism of action and experimental studies conducted on the same.

Keywords: Sinigrin; Cancer; Mustard

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References

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Citation

Citation: Anubhuti Sharma., et al. "Sinigrin: A Cancer Preventing Agent".Acta Scientific Cancer Biology 4.2 (2020): 01-05.



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