Anuj Kumar Singh1, Nand Kishor Roy1, Ajaikumar B Kunnumakkara1 and Piruthivi Sukumar2*
1Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India
2Schools of Medicine, University of Leeds, Leeds, UK
*Corresponding Author: Piruthivi Sukumar, Schools of Medicine, University of Leeds, Leeds, UK.
Received: November 04, 2019; Published: December 06, 2019
Oral cancer incidences increased to 354864 and death became 177384 according to GLOBOCAN 2018 but in India it is the commonest cancer in men and third commonest in women. With the recent development in the field of ion channel, they are becoming hot targets for treating various diseases including cancers. Arguably, the most important ion controls most of the cell signaling processes in almost all mammalian cells from division and differentiation to secretion and apoptosis is calcium (Ca2+). While there are many types of calcium ion management mechanisms are present in any given cell, one of the most important pathways of calcium movement, calcium permeable ion channels are discussed broadly in this review. We summarized the published literature on the role of calcium channels and pumps in oral cancer pathophysiology. We found most of the oral cancer work was in the areas of SERCA, PMCA and TRPs. DNA methylation leads to down regulation of human SERCA2 gene and PMCA1 gene which is considered as early events in case of oral squamous cell carcinoma (OSCC). Recently, role of TRPV1 and TRPA1 was reported in oral cancer pain where as TRPM8 in migration and invasion. This review starts with a short introduction on oral cancer and calcium handing mechanisms. Then we give in depth review of calcium channels, especially store operated calcium channels. Further, we summarize the recent literature on calcium channel regulation in oral cancer and briefly discuss the future research prospects in this area.
KeywordsOral Squamous Cell Carcinoma; Calcium Channels; OSCC; SERCA; PMCA; TRP; SOCC
Citation: Anuj Kumar Singh., et al. "Calcium Channels and Oral Cancer: A Short Review – History to Recent Advances".Acta Scientific Cancer Biology 4.1 (2020): 25-29.
Copyright: © 2020 Anuj Kumar Singh., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.