L Bubnovskaya1*, N Lukyanova1, A Belous2, S Solopan2, Yu Shlapa2, APodoltsev3 and A Kondratenko3
1R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Vasilkovskaya Ukraine, Europe
2V.I. Vernadsky Institute of General and Inorganic Chemistry, NAS of Ukraine, Palladin, Ukraine, Europe
3Institute of Electrodynamics, NAS of Ukraine, Peremoga, Ukraine, Europe
*Corresponding Author: L Bubnovskaya, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Vasilkovskaya Ukraine, Europe.
Received: December 30, 2019; Published: February 11, 2020
The aim of the study was to synthesize (La, Sr)MnO3 no particles as heating mediator and evaluate the ability of nano hyperthermia to affect ascitic forms of cancer as well tumor cells resistant to cytostatic. Nanoparticles have been synthesized by sol-gel method and magnetic fluid on the basis of nanoparticles was prepared. It is heated under alternating magnetic field (300kHz,7.7kA/m) and able to heat tumor cells. Nano hyperthermia is able to enhance the sensitivity of cisplatin resistant tumour cells (MCF-7Cp) to cytostatic action: about 30% of resistant tumor cells could overcome the resistance to cisplatin. Anti-tumor effect of nano hyperthermia was confirmed by the absence of ascitic fluid in peritoneal cavity of mice with lymphocytic leukaemia Р-388 (аscitic form). It may be explained by the ability of nanoparticles to penetrate into the tumor cells and to cause the phenomenon so named as “intracellular hyperthermia” as it was demonstrated by electron microscopy. Applying of nano hyperthermia using (La,Sr)MnO3 nanoparticles may be considered as the promising way to help in approaches to the problem of tumor cell resistance as alternative to the conventional chemotherapies. Nano hyperthermia intraperitoneal chemotherapy may be helpful within various multimodality strategies for prevention and treatment peritoneal carcinomatosis or malignant ascites.
Keywords:nanoparticles; magnetic fluid; nano hyperthermia; drug resistance, ascitic fluid, electron microscopy
Citation: ML Bubnovskaya., et al. “Some Effects of Nanohyperthermia on the Basis of Lanthanum-Strontium Manganites (La, Sr) Mno3 Nanoparticles as Heating Mediators. Acta Scientific Cancer Biology 4.3 (2020): 01-08.
Copyright: © 2020 ML Bubnovskaya., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.