Saheed Oluwasina Oseni and James Kwasi Kumi-Diaka*
Department of Biological Sciences, Florida Atlantic University, USA
*Corresponding Author: James Kwasi Kumi-Diaka, Department of Biological Sciences, Florida Atlantic University, USA.
Received: May 29, 2018; Published: June 14, 2018
Citation: Saheed Oluwasina Oseni and James Kwasi Kumi-Diaka. “Emerging Role of Cancer Stemness in Prostate Cancer Recurrence and Management". Acta Scientific Cancer Biology 2.5 (2018).
The importance of prostate cancer stemness in prostate tumor recurrence and mortality cannot be overemphasized and shouldn’t be trivialized. Intra-tumoral heterogeneity complicated by the presence and enrichment for prostate cancer stem cell (PCSC) population in prostate cancer (PCa) patient or survivors have been implicated in the initiation, progression, aggressiveness, metastasis, treatment failures and recurrence of the disease. More studies are needed to bring clarity to the molecular mechanisms of PCa stemness and its role in the development of castration-resistant PCa. In addition, selective and effective therapies are needed to target PCSCs to prevent PCa aggressiveness and recurrence. An overview of the role and molecular mechanisms of PCSCs, as well as some currently proposed diagnostic, prognostic and therapeutic methods for eradicating PCSCs to prevent PCa recurrence and psychological ‘fear of recurrence’, have been discussed and summarized.
Keywords: Prostate Cancer Stem Cells; Cancer Recurrence; Fear of Cancer Recurrence; Cancer Stemness; Castration-resistant Prostate Cancer
Copyright: © 2018 Saheed Oluwasina Oseni and James Kwasi Kumi-Diaka. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.