Acta Scientific Women's Health (ASWH)(ISSN: 2582-3205)

Research Article Volume 3 Issue 2

Beta vulgaris Impact on Splenic Toxicity Diclofenac-induced in Swiss Albino Mice

Hussah M Alobaid1*, Tahani M Al-Hazani2, Doaa M Elnagar1,3 and Norah A Althobaiti4

1Zoology Department, College of Science, King Saud University, Riyhad, Saudi Arabia
2Biology Department, College of Science and Humanities, Prince Sattam bin Abdulaziz University, Alkharj, Saudi Arabia
3Zoology Department, Faculty of Women, Ain Shams University, Cairo, Egypt
4Biology Department, College of Science and Humanities, Shaqra University, Al Quwaiiyah, Saudi Arabia

*Corresponding Author: Hussah M Alobaid, Zoology Department, College of Science, King Saud University, Riyhad, Saudi Arabia.

Received: December 22, 2020; Published: January 22, 2021

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Abstract

The present work aimed to investigate the possible effect of beetroot juice to overcome the splenic toxicity diclofenac - induced. 40 male albino mice were divided, 1st group deal as control group, 2nd treated with 8ml/kg of freshly prepared beetroot juice, 3rd treated with oral daily dose 20 mg/kg of diclofenac and 4th pre-treated with beetroot juice to diclofenac administration. Diclofenac treatment resulted in significant increase of liver and kidney functions, marked pathological alterations as diffusion of white pulp, minimized lymph nodes areas and volumes, increased pathological score, neutrophils and oxidative stress. The pre-treatment of beetroot to diclofenac revealed significant increase in liver and kidney functions, noticeable improvement in the spleen tissue manifested by decreasing of pathological score, neutrophils and oxidative stress.

Keywords: Spleen; Liver; Diclofenac; Beetroot; Pathological Score

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Citation

Citation: Hussah M Alobaid., et al. “Beta vulgaris Impact on Splenic Toxicity Diclofenac-induced in Swiss Albino Mice”. Acta Scientific Women's Health 3.2 (2021): 35-42.




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Acceptance rate35%
Acceptance to publication20-30 days
Impact Factor0.539

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