Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 5 Issue 1

Development of a Bio analytical Assay for the Determination of Rupatadine in Human Plasma and its Clinical Applications

Pankaj Dagur1, Gourav Rakshit1, Shreya Sharma1, Ankit Aggarwal1, Krishna Kant1, Ratna Ghosh2, Suddhasatya Dey3 and Manik Ghosh1

1Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India
2Birsa Educational Institutions and Research Foundation, Khunti, Jharkhand, India
3Bengal College of Pharmaceutical Sciences and Research, Durgapur, West Bengal, India

*Corresponding Author: Manik Ghosh, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India.

Received: December 07, 2020; Published: December 22, 2020

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Abstract

The latest corona-virus disease (nCOVID-19) which originated in Wuhan, China, and since then has been spreading around the world is a dangerous strain of corona-virus which is a highly communicable and morbific viral infection confirmed to cause by severe acute respiratory syndrome corona-virus 2 (SARS-CoV-2).Similarity index analysis in our study revealed that SARS-CoV-2 is related to SARS-CoV that had earlier emerged in 2002-03. The rapid transmission rates among humans and the severity of this new strain of CoV have made it a major concern worldwide. To date, the world is still lacking to approve clinically effective drugs or vaccines against COVID-19. Though clinical trials for some antiviral drugs have been tested to treat/prevent COVID-19, results are not satisfactory. As part of our response to the ongoing COVID-19 pandemic across the world, we in our current review have summarized and comparatively analyzed the sequence similarity of SARS-CoV-2 and previously identified other strains i.e. SARS-CoV(2002-03) and MERS-CoV (2012-14). We have also discussed the new potential approaches that could be effective for treating the symptoms related to nCOVID-19 to cope with this viral outbreak across the globe.

Keywords: COVID-19; SARS; MERS; Pathogenesis; Symptoms; Treatment Approaches

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Citation

Citation: Manik Ghosh., et al. “A Brief Understanding of COVID-19: Pathogenesis, Symptoms and Possible Treatment Approaches”. Acta Scientific Pharmaceutical Sciences 5.1 (2021): 70-79.



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