Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 5 Issue 1

Synthesis, Characterization and Antibacterial Evaluation of Some New Nickel(II) Complexes of a Tetraazamacrocycle

Pradip Paul1, Saswata Rabi1,2, Proma Kanungoe1, Sidratul Muntaha1, Debashis Palit1 and Tapashi Ghosh Roy1*

1Department of Chemistry, University of Chittagong, Chattogram, Bangladesh
2Department of Chemistry, Chittagong University of Engineering and Technology, Chattogram, Bangladesh

*Corresponding Author: Tapashi Ghosh Roy, Department of Chemistry, University of Chittagong, Bangladesh.

Received: November 20, 2020; Published: December 22, 2020

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Abstract

  Condensation of 1,2-diaminopropane with acetone in the presence of quantitative amount of perchloric acid, yielded a 14-membered octamethyl tetraazamacrocyclic dihydroperchlorate salt, Me8[14]diene.2HClO4 (L.2HClO4), which on extraction with chloroform at pH above 12 produced free ligand, L. The reaction between nickel(II) nitrate hexahydrate and the free ligand L resulted in a five coordinated square pyramidal light violet complex [NiL(NO3)](NO3). Moreover some substituted nickel(II) salts, Ni(NCS)2, NiCl2, NiBr2, NI2 and Ni(NO2)2 prepared in solution (with a possibility of existence of negligible amount of NO3- ion) by the interaction of nickel(II) nitrate hexahydrate with KX (X=SCN, Cl, Br or I) and NaNO2 respectively on reactions with the concerned ligand L furnished orange yellow [NiL](SCN)2 and light pink [NiL(NCS)](SCN), light purple [NiLCl]Cl, brownish [NiL]Br2 and light purple [NiLBr]Br, light purple [NiLI]I and light pink [NiL(NO2)](NO3) respectively. Among them, [NiL(NCS)](SCN), [NiLCl]Cl, [NiLBr]Br, [NiLI]I and [NiL(NO2)](NO3) were analysed as five coordinated square pyramidal and [NiL](SCN)2 and [NiL]Br2 as four coordinated square planar in geometry. All these complexes have been characterized on the basis of analytical, spectroscopic, conductometric and magnetochemical data. The antimicrobial activities of the ligand and its new nickel(II) complexes have been evaluated against some selected gram positive and gram negative bacteria.

Keywords: Tetraazamacrocyclic Ligand; Nickel(II) Complexes; Spectral Analysis; Antibacterial Evaluation

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Citation

Citation: Tapashi Ghosh Roy., et al. “Synthesis, Characterization and Antibacterial Evaluation of Some New Nickel(II) Complexes of a Tetraazamacrocycle". Acta Scientific Pharmaceutical Sciences 5.1 (2021): 60-69.



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