Abstract

  Aftimoon (Cuscuta reflexa Roxb.) is a parasitic plant used in the management of various skin disorders like vitiligo, pityriasis, mental disorder like depression, epilepsy, etc. and it is used as mufrad (single drug) in the form of powder, decoction, concoction etc and in the murakkab (compound formulations) form in the Unani system of medicine. The plant belongs to genus Cuscuta and family Cuscutaceae. This parasitic plant grows on different host plants in India upto thousands of feets and is found abundantly in the rainy season. It is yellowish in colour with thin swirly stem grows on other plants and trees as parasite commonly called as Dodder in English. Unani physicians have been using this plant since time immemorial to treat various illnesses pertaining to the disorder of humours in the body. A number of biologically active compounds like amarbelin, cuscutin, cuscutalin, etc have been isolated and important and significant pharmacological actions like anti-cancerous, anti-tumour, anti-inflammatory, antibacterial activities etc on aftimoon (Cuscuta reflexa Roxb) is reported in various studies. This paper aims to review and summarise knowledge presented in the classical Unani text and various scientific research being conducted on Cuscuta reflexa Roxb in order to generate a data based on evidences which will be helpful to the future research endeavours.

Keywords: Aftimoon; Cuscuta reflexa Roxb.; Parasitic Plant; Unani

References

1. Khare CP. “Indian Medicinal Plants: An illustrated dictionary”. New Delhi: Springer Verlag Berlin/Heidelberg, Springer science business media LLC (2007): 189.
2. Baitar Ibn and Al Jamiul. “Mufradat ul advia wal aghziya (Urdu translation, Part I)”. New Delhi: CCRUM; YNM: 54-56.
3. Ghani M and Khazainul Advia. Part III. Lahore: Sheikh Muhammad Basheer and Sons; YNM: 1039-1047.
4. Azam HM and Muheet-e-Azam. “Central Council for Research in Unani Medicine, part 1 (2002): 263.
5. “The Unani Pharmacoepia, Part I, Volume III”. New Delhi: CCRUM, Dept. of AYUSH, Ministry of H and FW, Govt. of India (2007): 1-2.
6. Nadkarni K. “The Indian Materia”. Medica Bombay: A.K Nadkarni Publishers 1 (1936): 482-483.
7. Kirtikar KR and Basu BD. “Indian Medicinal Plants, 3^rd edition”. Sri Satguru Publications, Delhi 8 (2001): 2401-2403.
8. William C Evans. “Trease and Evans Pharmacognosy”. Saunders Elsevier’s Publications, 16^th edition (2009): 37.
9. Kabeeruddin H. “Makhzan-ul-Mufradat Al-Maroof Khawas-ul-Advia”. Aijaz Publishing House, New Delhi, India (2000): 79-83.
10. “Standardisation of single drugs of unani medicine, Part II”. New Delhi: CCRUM, Ministry of H and FW, Govt. of India 7.8 (1992): 10-12.
11. “The Wealth of India-Raw Materials. New Delhi: National Institute of Science Communication and Information Resources, CSIR 10 (2003): 171-177.
12. “Qarabadeen Sarkari”. New Delhi: CCRUM, Ministry of H and FW, Govt. of Indi (2006): 7.
13. Sharma S., et al. “Comparative antioxidant activity of Cuscuta reflexa and Cassytha filiformis”. Journal of Pharmacy Research1 (2012): 441-443.
14. Mahmood N., et al. “Constituents of Cuscuto reflexa are anti-HIV Agents”. Antiviral Chemistry and Chemotherapy1 (1997): 70-74.
15. Pal DK., et al. “Antibacterial activity of Cuscuta reflexa stem and Corchorus olitorius seed”. Fitoterapia 7-8 (2006): 589-591.
16. Uddin Shaikh J., et al. “Swarnalin and cis-swarnalin, two new tetrahydrofuran derivatives with free radical scavenging activity, from the aerial parts of Cuscuta reflexa”. Natural Product Research7 (2007): 663-668.
17. Suresh V., et al. “In vitro anti-inflammatory and anti-cancer activities of Cuscuta reflexa Roxb”. Journal of Ethnopharmacology3 (2011): 872-877.
18. Chatterjee Dandopani., et al. “Evaluation of antitumor activity of Cuscuta Reflexa Roxb (Cuscutaceae) against Ehrlich ascites carcinoma in Swiss albino mice”. Tropical Journal of Pharmaceutical Research4 (2011): 447-454.
19. Gupta M., et al. “Studies on brain biogenic amines in methanolic extract of Cuscuta reflexa and Corchorus olitorius Linn. seed treated mice”. Acta Poloniae Pharmaceutica 60.3(2003): 207-210.
20. Anis Erum., et al. “α-glucosidase inhibitory constituents from Cuscuta reflexa”. Chemical and Pharmaceutical Bulletin1 (2002): 112-114.
21. Sharma Sakshy., et al. “Comparative study of Cuscuta reflexa and Cassytha filiformis for diuretic activity”. Pharmacognosy Research5 (2009): 327.
22. Bhattacharya Sanjib and Bodhisattva Roy. "Preliminary investigation on antipyretic activity of Cuscuta reflexa in rats”. Journal of Advanced Pharmaceutical Technology and Research1 (2010): 83.
23. Balakrishnan BR., et al. “Effect of methanol extract of Cuscuta reflexa aerial parts on hepatotoxicity induced by antitubercular drugs in rats”. International Journal of Applied Research in Natural Products 1 (2010): 18-22.
24. Thomas Sujith., et al. “Evaluation of anxiolytic effect of whole plant of Cuscuta reflexa”. World Journal of Pharmaceutical Sciences 4 (2015): 1245-1253.
25. Udavant Pavan Bhausaheb., et al. “In vitro anthelmintic activity of stems of Cuscuta reflexa”. International Journal of Bioassays (IJB) (2012).
26. Gilani Anwar-Ul Hassan and Khalid Aftab. "Pharmacological actions of Cuscuta reflexa”. International Journal of Pharmacognosy 4 (1992): 296-302.
27. Pal D., et al. “Evaluation of phychopharmacological effects of petroleum ether extract of Cuscuta reflexa stem in mice”. Acta Poloniae Pharmaceutica - Drug Research 60.6 (2003): 481-486.
28. Gupta M., et al. “Onset of puberty and ovarian steroidogenesis following adminstration of methanolic extract of Cuscuta reflexa stem and Corchorus olitorius Linn. seed in mice”. Journal of Ethnopharmacology 89.1 (2003): 55-59.
29. Pradhan D., et al. “Hepatoprotective activity of Cuscuta reflexa extract on experimental liver damage in rats”. Hamdard Medicus1 (2005): 129-131.
30. Pandit Shweta., et al. “Effect of Cuscuta reflexa Roxb on androgen‐induced alopecia”. Journal of Cosmetic Dermatology3 (2008): 199-204.
31. Rahmatullah Mohammed., et al. “Effect of Cuscuta reflexa stem and Calotropis procera leaf extracts on glucose tolerance in glucose-induced hyperglycemic rats and mice”. African Journal of Traditional, Complementary and Alternative Medicines2 (2010): 109-112.
32. Kalita Debajit and Jagat Saikia. "Ethonomedicinal, antibacterial and antifungal potentiality of Centella asiatica, Nerium indicum and Cuscuta reflexa–widely used in Tiwa Tribe of Morigaon district of Assam, India”. International Journal of Phytomedicine 4 (2012): 380-385.
33. Patel Satish., et al. “A study on the extracts of Cuscuta reflexa in treatment of cyclophosphamide induced alopecia”. DARU Journal of Pharmaceutical Sciences 22.1 (2014): 7.
34. Dokuparthi Sudheer Kumar., et al. “Phytochemical investigation and evaluation of antimutagenic activity of the extract of Cuscuta reflexa Roxb by Ames Test”. International Journal of Pharmaceutical Sciences and Research8 (2014): 3430.
35. Rath Diptirani., et al. “Identification of bioactive constituents from different fractions of stems of Cuscuta reflexa using GC-MS”. Natural Product Research 32.16 (2018): 1977-1981.
36. Kaur Amanpreet., et al. “Effect of ethanolic extract of Cuscuta reflexa on high fat diet-induced obesity in Wistar rats”. Obesity Medicine 14 (2019): 100082.
37. Jadhav GB., et al. “Effect of Cuscuta reflexa extract on Experimentally Induced Hypertension in normal and Streptozotocin Induced Diabetes in Rats”. Research Journal of Pharmacy and Technology3 (2020): 1351-1355.
38. Cuscuta reflexa (dodder). CABI (2020).
39. USDA PLANTS Cuscuta reflexa Roxb (2020).

Citation

Citation: Aaisha Ansari., et al. “Aftimoon (Cuscuta reflexa Roxb.): A Parasitic Plant with Therapeutic Potentials". Acta Scientific Pharmaceutical Sciences 4.11 (2020): 90-97.

Copyright

Copyright: © 2020 Aaisha Ansari., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.