A Supriya*, J Sundaraseelan, BR Srinivas Murthy and M Bindu Priya

Department of Pharmaceutics, Jawaharlal Nehru Technological University Anantapur, India

*Corresponding Author: A Supriya, Department of Pharmaceutics, Sri Padmavathi School of Pharmacy, Jawaharlal Nehru Technological University Anantapur, India.

Received: December 29, 2017; Published: January 20, 2018

Citation: A Supriya., et al. “Formulation and In vitro Characterization of Neomycin Loaded Chitosan Nanoparticles”. Acta Scientific Pharmaceutical Sciences 2.2 (2018).

Abstract

  The main objective of this work is to formulate and evaluate of neomycin loaded chitosan nanoparticles and to extend the drug release time by the preparation of Nanoparticles using ionic gelation method. In present work different formulations were prepared by using different ratios of polymer, and sodium tri polyphosphate (cross linking agent). Prepared Nanoparticle was evaluated for its Particle Size, zeta potential, scanning electron microscopy, Percentage practical yield, Drug Entrapment Efficiency, anti-microbial studies and In-Vitro drug release studies. The optimized CSNPs was found percentage practical yield was 87.7%. Entrapment efficiency (%EE) of 65.5%, scanning electron microscopy round shape and smooth surface. The in-vitro release profile was found to be 96.65% sustained up to 330 minutes. Thus, incorporation of Neomycin into CSNPs results in enhanced the drug release when compared to pure drug.

Keywords: Neomycin Sulphate; Sodium Tripolyphosphate; Chitosan; Ionic Gelation Method; Anti-Microbial Studies

Copyright: © 2018 A Supriya., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.