Saroj Makwana¹, Sanman Samova²*, Rajesh Kharadi¹ and Kalpesh Patel¹

¹B.K.Mody Government Pharmacy College, Rajkot, Gujarat, India
²Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad, India

*Corresponding Author: Sanman Samova, Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad, India.

Received: September 18, 2017; Published: October 31, 2017

Citation: Sanman Samova., et al. “Formulation and Characterization of Sublingual Tablets Containing Nicardipine Hydrochloride”. Acta Scientific Pharmaceutical Sciences 1.5 (2018).

Abstract

  Nicardipine hydrochloride is a Calcium channel blocker. It is used in the treatment of Angina having low bioavailability about 10 - 40% orally is attributed to the hepatic first pass metabolism. The purpose of present research was to formulate sublingual tablets of Nicardipine hydrochloride. For Preparation of sublingual tablets disintegration time was set by carrying out ex-vivo permeation study of drug- β-Cyclodextrin. The Sub-lingual tablets were prepared using Sodium starch glycolate, Croscarmellose sodium, Crospovidone as super disintegrating agent and microcrystalline cellulose, PVP K 30 as a binder by direct compressible technique and evaluated for various parameter. Stability study of optimized formulation was performed as per ICH guideline. The in-vitro disintegration time of the optimized formulation (F4) was 41 seconds and showed 99.45% drug release within 8 minutes. Formulation containing 4% Crospovidone and 2% PVP K 30 (Batch F4) show highest disintegration and ex-vivo permeation was 96.81% within 14 minutes. Optimized formulation was stable for 10 days during stability study as per ICH guideline.

Keywords: Nicardipine Hydrochloride; β-Cyclodextrin; PVP K 30; Crospovidone; Ex-vivo Permeation Study; In-vitro Disintegration Time

Copyright: © 2018 Sanman Samova., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.