Abstract

Background: Some studies have shown that elevated plasma C-reactive protein (CRP) levels in acute ischaemic stroke are associated with stroke severity and early prognosis while low serum triiodothyronine (T3) levels are associated with poor prognosis. The aim of this study is to evaluate whether serum CRP and T3 are independent predictors of stroke severity and early prognosis in patients with acute ischaemic stroke.

Material and Method: A total of 716 patients hospitalized with the diagnosis of acute ischaemic stroke were included in the study. The patients did not have any known infectious or thyroid diseases. NIHSS score was used to evaluate clinical stroke severity and patients were grouped as mild (<8), moderate (8-14) and severe (> 14) stroke. Modified Rankin Score was used on the 10th day to evaluate early prognosis and patients were grouped as good prognosis (mRS:0-2) and poor prognosis (mRS:3-6). The relationship between serum CRP and free T3 levels and stroke severity and early prognosis were investigated.

Results: There was a significant difference in CRP and T3 levels (p:0.007 and p:0.01, respectively) according to stroke severity. Higher NIHHS scores were correlated with higher

CRP levels (rho=.283, p = 0.001) and lower T3 levels (rho= -.188, p = 0.001). Patients with poor functional outcomes had high CRP levels (rho=.110, p = 0.01) and low T3 levels (rho= -.184, p = 0.001)

Conclusion: Statistically significant relationship between stroke severity and early prognosis and CRP and T3 levels in patients with acute ischaemic stroke suggests that CRP and T3 levels may be a predictor of prognosis in acute ischaemic stroke.

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Citation

Citation: Füsun Mayda Domaç., et al. “Can C-Reactive Protein and T3 be Predictive for Prognosis in Ischaemic Stroke?".Acta Scientific Neurology 3.10 (2020): 33-38.

Copyright

Copyright: © 2020 Füsun Mayda Domaç., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.