Abstract

 Schizophrenia is a chronic psychotic illness with multifactorial etiology that manifests with a constellation of positive, negative, affective and cognitive symptoms [1]. As we are learning more about the neurobiology of schizophrenia, the role of the prefrontal cortex (PFC) in schizophrenia has become more evident. While various medications are available to treat psychotic symptoms in schizophrenia, treatment of cognitive functions, residual symptoms and comorbid disorders is still a substantial challenge. Here we present a case of a young male who suffers from schizophrenia, with a previous diagnosis of ADHD and substance abuse, who showed remarkable improvement following treatment with the alpha-2A adrenergic agonist guanfacine, likely related to enhanced PFC function.

Keywords: Schizophrenia; Prefrontal Cortex (PFC); Dopaminergic (DA)

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Citation

Citation: Prajjita Sarma Bardoloi. “Enhancement of Function of the Prefrontal Cortex to Improve Symptoms of Schizophrenia".Acta Scientific Neurology 3.5 (2020): 19-23.

Copyright

Copyright: © 2020 Prajjita Sarma Bardoloi. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.