Bhavna Tyagi1*, Deepak Bhargava1, Ritika Sharma1,Vidyadevi Chandarvarkar1 and Pradeep Sundersan2
1Oral and Maxillofacial Pathology and Microbiology, Sharda University, India
2Ph.D (Education), American University, London, UK
*Corresponding Author: Bhavna Tyagi, Oral Pathologist, Oral and Maxillofacial Pathology and Microbiology, Sharda University, Greater Noida, Uttar Pradesh, India.
Received: December 14, 2020; Published: January 23, 2021
Context: Oral submucous fibrosis (OSMF) is documented as a potentially malignant disorder with a 7.6% malignant transformation rate. Various trace elements such as, copper, zinc, and iron are getting much attention in the early recognition of cancer and potentially malignant disorders including OSMF.
Aim: To evaluate the levels of copper in the OSMF patients’ blood serum and compare with healthy individuals.
Settings and Design: Quantitative research was conducted in the Department of Oral and Maxillofacial Pathology, Sharda University, Greater Noida. A total of 80 participants, out of which 20 participants were case-control (Batch I), and 60 diagnosed OSMF patients (cases) (Batch II, III and IV) participated.
Methods and Material: For estimation of serum copper, under sterile conditions, 3ml of the venous blood sample was collected. Serum was collected and evaluated by adding an instructed proportion of buffer, and the color reagents in the clean glassware.
Statistical Analysis: All the data was systematically tabulated and analyzed using SPSS statistical software by employing “One way ANOVA”.
Results: The mean serum copper (µg/dl) level differed significantly (p < 0.004) between all the batches. Mean serum copper (µg/dl) levels in Batch I, Batch II, Batch III, Batch IV was 103.43 ± 5.88603, 105.1 ± 5.99034, 121.55 ± 8.08817, 134.825 ± 18.23334, respectively.
Conclusion: Serum copper levels can be used as a potential diagnostic and prognostic marker in the patient with OSMF condition.
Keywords: Oral Submucous Fibrosis; Trace Elements; Copper; Pre-Cancer; Diagnostic Marker; Serum Copper
Citation: Bhavna Tyagi.,et al. “Estimation of Serum Copper Levels in Oral Submucous Fibrosis Patients: A Quantitative Study”. Acta Scientific Dental Sciences 5.2 (2021): 99-104.
Copyright: © 2021 Bhavna Tyagi.,et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.