Acta Scientific Clinical Case Reports

Review Article Volume 1 Issue 5

Introducing COVID-19 as an Evolutionary Metabolic Infectious Disease (EMID)

Sorush Niknamian*

Military Medicine Department, Liberty University, Virginia, Lynchburg, USA

*Corresponding Author: Sorush Niknamian, Military Medicine Department, Liberty University, Virginia, Lynchburg, USA.

Received: May 07, 2020; Published: May 22, 2020

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Abstract

Background: Coronaviruses are a group of related viruses that cause diseases in mammals and birds. In humans, coronaviruses cause respiratory tract infections that can range from mild to lethal. Mild illnesses include some cases of the common cold, while more lethal varieties can cause SARS, MERS, and COVID-19. The outbreak was identified in Wuhan, China, in December 2019, declared to be a Public Health Emergency of International Concern on 30 January 2020, and recognized as a pandemic on 11 March 2020. Introduction: Coronaviruses are the subfamily Orthocoronavirinae, within the family of Coronaviridae, order Nidovirales, and realm Riboviria. They are enveloped viruses with a positive-sense single-stranded RNA genome and a nucleocapsid of helical symmetry. The genome size of coronaviruses is approximately from 26 to 32 kilobases. Coronaviruses were first discovered in the 1930s and Human coronaviruses were discovered in the 1960s. The earliest ones studied were from human patients with the common cold, which were later named human coronavirus 229E and human coronavirus OC43. Other human coronaviruses have since been identified, including SARS-CoV in 2003, HCoV NL63 in 2004, HKU1 in 2005, MERS-CoV in 2012, and SARS-CoV-2 in 2019. Most of these have involved serious respiratory tract infections.

Results and Discussion: Based on our multidisciplinary research, we have found the major cause and some treatments methods for fighting this powerful pathogen. The prime cause of COVID-19 is pushing the mitochondrial to lose MMP. A loss of the MMP by any mechanism leads to functional and structural collapse of the mitochondria and cell death. Mitophagy plays an important role in maintaining mitochondrial homeostasis but can also eliminate healthy mitochondria in cases such as cell starvation, viral invasion and erythroid cell differentiation. The mitochondrial fusion and fission are highly dynamic. Viruses specially COVID-19, interfere with these processes to distort mitochondrial dynamic to facilitate their proliferation. Thus, interfering with these processes promotes the interference of different cellular signaling pathways. The severe acute respiratory syndrome coronavirus (SARS-CoV) escapes the innate immune response by translocating its ORF-9b to mitochondria and promotes proteosomal degradation of dynamin-like protein (Drp1) leading to mitochondrial fission. We also researched on Ultrasonic Energy to destroy the virus which lead to positive results but it needs more future research. The most destructive way of viruses is to enhance Reactive Oxygen Species (ROS) and free radicals in human contaminated cell which cause inflammation in a host cell. ELF-EMF convert free radicals into less active molecules and eliminate them into two pathways which has been discussed in the discussion part. Using ELF-EMF affects the second pathway that relies on the activity of the catalase and superoxide dismutase enzymes which is the most effective pathway. For the best result of treatment, is the use of low-frequency magnetic fields (LFMF) plus EMF-ELF which penetrate into deeper tissues, cells and mitochondria. We also have gone through many researches since 1920 and found if we emit the frequency as the same frequency of COVID-19, can cause resonance in the virus and destroy it. So, we measured the SARS-CoV-2 frequency by Cyclotron and calculated the frequency of the virus is 30 KHz - 500 KHz.

Conclusion: COVID-19 (SARS-CoV-2) is one of the most complex virus which has been discovered since 2020. Until today, there has been no Antiviral Drug which can be useful in the treatment of this infectious disease has been discovered till today. COVID-19 genomic sequence containing SARS-CoV, MERS-CoV and Influenza A. Therefore, there is a high possibility of continuing COVID-19 even in summer. To gain the best result in treatment, we should use low-frequency magnetic fields (LFMF) plus EMF which penetrate into deeper tissues, cells and mitochondria in order to reduce ROS and Inflammation. In order to destroy SARS-CoV-2 virus in environment and also in infected individuals, we should use ELF-EMF plus LFMF. We also have gone through many researches since 1920 and found if we emit the frequency as the same frequency of COVID-19, it can cause resonance in the virus and destroy it. So, we measured the SARS-CoV-2 frequency by Cyclotron and calculated the frequency of the virus that id is 30 KHz - 500 KHz. The differences in the frequencies is due to the size of the virus which is from 26 to 32 Kilobases.

Keywords: COVID-19; Mitochondria; Cyclotron; Resonance; Frequency; MMP; Royal Raymond Rife Protocol; Ultrasound Energy; LFMF; ELF-EMF; Immunodeficiency; Immune Response; Protein Mismatch in COVID-19

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References

  1. "Virus Taxonomy: 2018b Release". International Committee on Taxonomy of Viruses (ICTV) (2019).
  2. "2017.012-015S" (xlsx). International Committee on Taxonomy of Viruses (ICTV) (2018).
  3. "ICTV Taxonomy history: Orthocoronavirinae". International Committee on Taxonomy of Viruses (ICTV) (2020).
  4. Fan Y., et al. “Bat Coronaviruses in China". Viruses 3 (2019): 210.
  5. Groot RJ., et al. “Family Coronaviridae". In King AM, Lefkowitz E, Adams MJ, Carstens EB, International Committee on Taxonomy of Viruses, International Union of Microbiological Societies. Virology Division (eds.). Ninth Report of the International Committee on Taxonomy of Viruses. Oxford: Elsevier (2011): 806-828.
  6. International Committee on Taxonomy of Viruses (2010-08-24). "ICTV Master Species List v10" (xls) (2009).
  7. Woo Patrick CY., et al. “Coronavirus Genomics and Bioinformatics Analysis". Viruses 8 (2010): 1804-1820.
  8. Almeida JD., et al. “Virology: Coronaviruses". Nature 5168 (1968): 650.
  9. Lau Hien., et al. “Internationally lost COVID-19 cases". Journal of Microbiology, Immunology and Infection (2020).
  10. WHO–China Joint Mission (16–24 February 2020). "Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19)" (PDF)”. World Health Organization (2020).
  11. Cyranoski D. "Mystery deepens over animal source of coronavirus". Nature7797 (2020): 18-19.
  12. Preslar D and Borger J. “Body Piercing Infections”. In: StatPearls [Internet]. Treasure Island (FL): Stat Pearls Publishing (2020).
  13. Grant SS and Hung DT. “Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response”. Virulence 4 (2013): 273-283.
  14. Nenah Sylver. “Desert Gate the Rife Handbook of Frequency Therapy and Holistic Health” (2011).
  15. Lawrence R Freedman. “Infective Endocarditis and Other Intravascular Infections”. Current Topics in Infectious Disease (2012).
  16. Royal R Rife. “A Rare Recording of Dr. Royal R. Rife”. Publisher: Listen and Live Audio. Unabridged Audiobook (2018).
  17. Goldsmith CS., et al. “"Ultrastructural characterization of SARS coronavirus". Emerging Infectious Diseases 2 (2004): 320-326.
  18. Neuman BW., et al. “Supramolecular architecture of severe acute respiratory syndrome coronavirus revealed by electron cryomicroscopy". Journal of Virology16 (2006): 7918-7928.
  19. Fehr AR., et al. “"Coronaviruses: an overview of their replication and pathogenesis". Methods in Molecular Biology Springer1282 (2015): 1-23.
  20. Lai MM and Cavanagh D. "The molecular biology of coronaviruses". Advances in Virus Research 48 (1997): 1-100.
  21. Chang CK., et al. “The SARS coronavirus nucleocapsid protein-forms and functions". Antiviral Research 103 (2014): 39-50.
  22. Neuman BW., et al. “A structural analysis of M protein in coronavirus assembly and morphology". Journal of Structural Biology1 (2011): 11-22.
  23. Reshi L., et al. “Anti-apoptotic genes Bcl-2 and Bcl-xL overexpression can block iridovirus serine/threonine kinase-induced Bax/mitochondria-mediated cell death in GF-1 cells”. Fish and Shellfish Immunology 61 (2017): 120-129.
  24. Peterhans E., et al. “Virus-induced formation of reactive oxygen intermediates in phagocytic cells”. Free Radical Research Communications1-5 (1987): 39-46.
  25. Vierucci A., et al. “A mechanism for liver cell injury in viral hepatitis: Effects of hepatitis B virus on neutrophil function In vitro and in children with chronic active hepatitis”. Pediatric Research10 (1983): 814-820.
  26. Muller F. “Reactive oxygen intermediates and human immunodeficiency virus (HIV) infection”. Free Radical Biology and Medicine6 (1992): 651-657.
  27. Boya P., et al. “Antioxidant status and glutathione metabolism in peripheral blood mononuclear cells from patients with chronic hepatitis C”. Journal of Hepatology5 (1999): 808-814.
  28. Bianchi GP., et al. “Nutritional effects of oral zinc supplementation in cirrhosis”. Nutrition Research8 (2000): 1079-1089.
  29. Reshi L., et al. “RNA viruses: ROS-mediated cell death”. International Journal of Cell Biology (2014): 467-452.
  30. Reshi L., et al. “Aquatic viruses induce host cell death pathways and its application”. Virus Research 211 (2016): 133-144.
  31. Reshi L and Hong JR. “Mitochondria as a favorite organelle for invading viruses”. Molecular Biology 6 (2017): 181.
  32. Reshi L., et al. “RNA viruses: ROS-mediated cell death”. International Journal of Cell Biology (2014): 467-452.
  33. Machida K., et al. “Hepatitis C virus infection activates the immunologic (type II) isoform of nitric oxide synthase and thereby enhances DNA damage and mutations of cellular genes”. Journal of Virology16 (2004): 8835-8843.
  34. Reshi L., et al. “Aquatic viruses induce host cell death pathways and its application”. Virus Research 211 (2016): 133-144.
  35. Machida K., et al. “Hepatitis C virus infection activates the immunologic (type II) isoform of nitric oxide synthase and thereby enhances DNA damage and mutations of cellular genes”. Journal of Virology 16 (2004): 8835-8843.
  36. Reshi L and Hong JR. “Mitochondria as a favourite organelle for invading viruses”. Molecular Biology 6 (2017): 181.
  37. Meng G., et al. “Mitophagy promotes replication of oncolytic Newcastle disease virus by blocking intrinsic apoptosis in lung cancer cells”. Oncotarget 15 (2014): 6365-6374.
  38. Xia M., et al. “Mitophagy switches cell death from apoptosis to necrosis in NSCLC cells treated with oncolytic measles virus”. Oncotarget 11 (2014): 3907.
  39. Valko M., et al. “Free radicals and antioxidants in normal physiological functions and human disease”. The international Journal of Biochemistry and Cell Biology44 (2007): 84.
  40. Moore K and Roberts JL. “Measurement of lipid peroxidation”. Free Radical Research 28 (1998): 659-671.
  41. Foletti A., et al. “Cellular ELF signals as a possible tool in informative medicine”. Electromagnetic Biology and Medicine.1 (2009): 79.
  42. Barry Lynes. “Rife's World of Electromedicine: The Story, the Corruption and the Promise” (2009).
  43. Guerriero F and Ricevuti G. “Extremely low frequency electromagnetic fields stimulation modulates autoimmunity and immune responses: a possible immuno-modulatory therapeutic effect in neurodegenerative diseases”. Neural Regen Res.12 (2016):1888-1895.
  44. Patruno A., et al. “Effects of extremely low frequency electromagnetic field (ELF-EMF) on catalase, cytochrome P450 and nitric oxide synthase in erythro-leukemic cells”. Life Sciences 121 (2015): 117-123.
  45. Simkó M and Mattsson MO. “Extremely low frequency electromagnetic fields as effectors of cellular responses In vitro: possible immune cell activation”. Journal of Cellular Biochemistry 1 (2004): 83-92.
  46. Komaki A., et al. “Effects of exposure to an extremely low frequency electromagnetic field on hippocampal long-term potentiation in rat”. Brain Research 1564 (2014): 1-8.
  47. Zhang Y., et al. “Short-term effects of extremely low frequency electromagnetic fields exposure on Alzheimer's disease in rats”. International Journal of Radiation Biology 1 (2015): 28-34.
  48. Akbarnejad Z., et al. “Spatial memory recovery in Alzheimer's rat model by electromagnetic field exposure”. International Journal of Neuroscience 8 (2018): 691-696.
  49. Mahaki H., et al. “A review on the effects of extremely low frequency electromagnetic field (ELF-EMF) on cytokines of innate and adaptive immunity”. Electromagnetic Biology and Medicine 1 (2019): 84-95.
  50. Simkó M and Mattsson MO. “Extremely low frequency electromagnetic fields as effectors of cellular responses in vitro: possible immune cell activation”. Journal of Cellular Biochemistry 1 (2004): 83-92.
  51. Kirson E., et al. “Chemotherapeutic treatment efficacy and sensitivity are increased by adjuvant alternating electric fields”. BMC Medical Physics 9 (2009): 1.
  52. Banik S., et al. “Bioeffects of microwave-a brief review”. Bioresource Technology2 (2003): 155.
  53. Woo Joseph. "A short History of the development of Ultrasound in Obstetrics and Gynecology". esource Discovery Network, University of Oxford (2012).
  54. K Billah and R Scanlan. “Resonance, Tacoma Narrows Bridge Failure, and Undergraduate Physics Textbooks”. American Journal of Physics2 (1991): 118-124.
  55. , et al. United States Patent 4,524,295 (1985).
  56. Robach Y., et al. “Ultrasonic absorption evidence for structural fluctuations in frog virus 3 and its subparticles”. Proceedings of the National Academy of Sciences of the United States of America 80 (1983): 3981.
  57. Cerf R. “Absolute measurement of enhanced fluctuations in assemblies of biomolecules by ultrasonic techniques”. Biophysical Journal 47 (1985): 751.
  58. Babincová M., et al. “Resonant absorption of ultrasound energy as a method of HIV destruction”. Medical Hypotheses 55 (2000): 450.
  59. Dykeman EC and Sankey OF. “Low Frequency Mechanical Modes of Viral Capsids: An Atomistic Approach”. Physical Review Letters (2008).
  60. Balandin AA and Fonoberov VA. “Vibrational modes of nano-template viruses”. Journal of Biomedical Nanotechnology 1 (2005): 90.
  61. Dykeman E and Sankey OF. “Atomistic modeling of the low-frequency mechanical modes and Raman spectra of icosahedral virus capsids”. Physical Review E 81 (2010): 021918.
  62. Tsen KT., et al. “Raman scattering studies of the low-frequency vibrational modes of bacteriophage M13 in water-observation of an axial torsion mode”. Nanotechnology 17 (2006): 5474.
  63. Liu TM., et al. “Microwave resonant absorption of viruses through dipolar coupling with confined acoustic vibrations”. Applied Physics Letters 94 (2009): 043902.
  64. Liu TM., et al. “Effects of hydration levels on the bandwidth of microwave resonant absorption induced by confined acoustic vibrations”. Applied Physics Letters 95 (2009): 173702.
  65. Rocha EPC., et al. “Comparisons of dN/dS are time dependent for closely related bacterial genomes". Journal of Theoretical Biology2 (2006): 226-235.
  66. Ray Abel. “Frequency: Harness the power of human Frequency and change your life forever” (2016).
  67. Penney Peirce. “Frequency: The Power of Personal Vibration” (2011).
  68. Jeong-Min Kim A., et al. “Identification of Coronavirus Isolated from a Patient in Korea with COVID-19”. Osong Public Health Res Perspect 11.1 (2020): 3-7.
  69. https://www.fcc.gov/engineering-technology/electromagnetic-compatibility-division/radio-frequency-safety/faq/rf-safety
  70. Hemida MG., et al. “Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia, 2010 to 2013". Euro Surveillance50 (2013): 20659.
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Citation

Citation: Sorush Niknamian. “Introducing COVID-19 as an Evolutionary Metabolic Infectious Disease (EMID)”. Acta Scientific Clinical Case Reports 1.5 (2020): 08-16.




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