Abstract

Background: The p16INK4a has been identified as a biomarker for lesions caused by HPV, and its presence with Ki-67 immunostains has been proposed as a diagnostic tool for neoplastic pre invasive lesions. Is well known the association between HPV and certain kinds of head and neck squamous cell carcinoma (HNSCC.) The purpose of this study was to determine the use of P16/Ki-67 immunostains in the diagnosis of neoplastic intramucosal pre invasive lesions of head and neck.

Methods: A series 20 biopsies of intramucosal lesions from oral cavity and larynge. We used tissue microarray technique and performed immunostains for P16/Ki-67.

Results: Histological diagnosis was papillomatosis, squamous hyperplasia and dysplasia. Unexpected 60% were female and 40% were man. 13% evolved to a squamous cell carcinoma between 1 month and 5 years. 13% express P16/Ki-67 immunostains. All patients positive Ki-67 evolve to HNSCC.

Conclusion: The series is too short; we were not able to find association between p16/Ki-67 and variables. Data suggests that Ki-67 as biomarker predicting a higher risk of becoming and invasive carcinoma. In addition, the utility of p16 as biomarker of HPV lesions has to be confirm with molecular diagnosis.

Keywords: p16INK4a; HPV; Ki 67; Head and Neck Squamous Carcinoma; Intra Mucosal Lesion; Papillomatosis

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Citation

Citation: Massiel S Fernández B.,et al. “Expression of P16^INK4A and KI 67 in Diagnosis of Head and Neck Intraepithelial Lesions". Acta Scientific Cancer Biology 4.8 (2020): 14-20.

Copyright

Copyright: © 2020 Massiel S Fernández B.,et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.